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FLASH GENE

Symbol

SHISA5

contributors: mct - updated : 20-11-2009

HGNC name	shisa homolog 5 (Xenopus laevis)
HGNC id	30376

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3p21.31      Physical location : 48.509.196 - 48.541.661
Synonym name	scotin
	putative NFkB activating protein 120
Synonym symbol(s)	SCOTIN, PSEC0133

DNA

TYPE	functioning gene
STRUCTURE	32.46 kb     6 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016479 6 - 2166 NP_057563 25 240 - 2007 17889823

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune thymus       highly Reproductive female system placenta     highly   female system ovary     moderately   female system uterus cervix   moderately Urinary bladder       moderately

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	. an N-terminal signal sequence
	a MYB DNA-binding domain repeat
	a central transmembrane domain composed of 18 hydrophobic amino acids
	a proline/tyrosine domain required for endoplasmic reticulum (ER) localization
	PRD C-terminal region containing the PDCD6 binding site

HOMOLOGY

interspecies

ortholog to murine Scotin

Homologene

FAMILY

shisa protein family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,nucleus
	intracellular,nuclear envelope

basic FUNCTION	involved in positive regulation of I-kappaB kinase/NF-kappaB cascade
	pro-apoptotic gene, induced upon DNA damage or cellular stress in a TP53-dependent manner, and one of the ways by which Scotin induces apoptosis is by causing cell cycle arrest

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

binding

RNA

small molecule

protein	TP53
	PDCD6 target protein ( binding of PDCD6 to Scotin was demonstrated to be strictly calcium dependent indicating a role of this interaction in calcium signaling pathways)
	TP63 target gene induced during epithelial differentiation, a complex process that also involves ER stress induction
	interacting with TP73 (induces ER stress via the direct transactivation of Scotin)
	interacts with PDCD6

cell & other

REGULATION

activated by

p53

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS