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FLASH GENE
Symbol SHC1 contributors: mct/npt/pgu - updated : 08-01-2010
HGNC name SHC (Src homology 2 domain containing) transforming protein 1
HGNC id 10840
Location 1q21      Physical location : 154.934.774 - 154.946.959
Synonym name
  • Src homology collagen-like) adaptor protein
  • SH2 domain protein C1
  • Synonym symbol(s) SHCA, FLJ26504, SHC, p52SHC, p66SHC, p66
    DNA
    TYPE functioning gene
    STRUCTURE 12.18 kb     12 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    KCNN3 1q21.3 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 PMVK 1p13-q23 phosphomevalonate kinase PBXIP1 1q22 pre-B-cell leukemia transcription factor interacting protein 1 PYGO2 1q22 pygopus 2 SHC1 1q21 SHC (Src homology 2 domain containing) transforming protein 1 CKS1B 1q21.2 CDC28 protein kinase regulatory subunit 1B PP591 1q22 FAD-synthetase LENEP 1q22 lens epithelial protein ZFP67 1q21.2 zinc finger protein 67 homolog (mouse) FLJ32934 1q22 hypothetical protein FLJ32934 FLJ32785 1q22 hypothetical protein FLJ32785 ADAM15 1q21.3 a disintegrin and metalloproteinase domain 15 (metargidin) EFNA4 1q21-q22 ephrin-A4 EFNA3 1q21-q22 ephrin-A3 EFNA1 1q21-q22 ephrin-A1 LOC55974 1q22 stromal cell protein DPM3 1q21.2 dolichyl-phosphate mannosyltransferase polypeptide 3 KCP2 TRIM46 1q21-22 tripartite motif-containing 46 MUC1 1q21 mucin 1, transmembrane THBS3 1q21-q23 thrombospondin 3 MTX1 1q21 metaxin 1
    RNA
    TRANSCRIPTS type messenger
    text three isoforms (p46, p52, p66)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3195 52 474 - 2008 18279888
  • p52SHC or variant 2
  • interacting with TRIM31
  • 12 - 3493 62.8 583 - 2008 18279888
  • genetic determinant of life span implicated in the regulation of receptor signaling and various mitochondrial functions
  • inducing mitochondrial DNA replication
  • p66SHC or variant 1
  • 12 - 3496 - 584 - 2008 18279888
    13 - 3192 - 473 - 2008 18279888
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly
    Reproductivemale systemprostate  highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text neural stem cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal phosphotyrosine binding domain
  • a central collagen homologous region (CH1), with three tyrosine residues that are known to become phosphorylated
  • a proline-rich region (binding SHS) motifs
  • a SH2 C terminal motif, lacking a catalytic unit
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adaptor , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • transduction adaptor protein SHC
  • signaling adapter that couples activated growth factor receptors to signaling pathway
  • plays a crucial role in linking stimulated receptors to mitogen-activated protein kinase activation through the formation of dynamic signalling complexes
  • play a non-redundant role in cytoskeletal reorganization-induced Erk activation by cytochalasin D
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of multimeric complexes with EGFR, SOS, GRB2
  • GRB2/GAB2/SHC1/LRRK1 signal integrator complex is functionally involved in the balance of cellular stress responses
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with GRB2 independently of IRS1
  • bind the tyrosine-phosphorylated CD247 chain of the receptor via its src homology 2 (SH2) domain, delivering signals that control T cell development and activation
  • cell & other
    REGULATION
    Other tyrosine-phosphorylated during insulin and EGFR stimulation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS