protein
| specific interactions of SH3 domains with the PXXXPR motif in CBL play multiple roles in down-regulation of receptor tyrosine kinases |
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competition between CBL and ubiquitin binding to SH3KBP1 regulates CBL function and EGFR endocytosis |
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MAP3K4 is a SH3KBP1-interacting partner (enhances the activation of MKK6 and of the downstream MAPK14 following oxidative stress and growth factor stimulation) |
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endocytic scaffold protein, as a putative dendrin-interactor |
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interacting with ATXN2 |
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binding partner of nephrin and podocin and regulates the internalization of the slit diaphragm complex |
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functional competition of CD2AP and SH3KBP1 for binding to nephrin and podocin (when both proteins are coexpressed, nephrin and podocin bind preferentially to CD2AP) |
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interacts with endocytic regulators such as dynamin and endophilins in the striatum |
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induced SERPINE1 mRNA and protein expression both under normoxia and hypoxia (induces SERPINE1 expression via modulation of HIF1A stability) |
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indirectly link the EGFR to the endocytic machinery at the plasma membrane, is also thought to be involved in receptor internalization |
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direct interaction between DNM2 and SH3KBP1 that is induced by EGFR stimulation and, most surprisingly, occurs late in the endocytic process |
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ARAP1 interaction with SH3KBP1 regulates endocytic trafficking of the EGFR and affects ubiquitination of EGFR |
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INPPL1 interacting with SH3KBP1 (this interaction might synergistically facilitate the down-regulation of phosphatidylinositol-3,4,5-trisphosphate levels) |
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novel role for CD2AP in regulating posttranslational modification of SH3KBP1 |
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required for CBL-mediated regulation of BCR signaling and for downstream events such as survival, growth, and differentiation of human B cells |
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ubiquitination of EGFR by CBL and its cognate adaptor SH3KBP1 play an essential role in directing this receptor to the lysosome for degradation |
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interaction of SH3KBP1 with MAP3K4 was increased during the late phase of TNFSF10 incubation, suggesting that sustained MAPK14 and HSPB1 phosphorylation protects cells by preventing further cell death |
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DAB1 suppresses SH3KBP1 phosphorylation at Ser587 |
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SH3KBP1 participates in RELN signaling through the binding to DAB1 |
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interacts with ESCRT components for protein sorting in endosomes |
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SH3KBP1-SEPT9 is localized exclusively to the plasma membrane, where SEPT9 is recruited to EGF-engaged receptors in a SH3KBP1-dependent manner |
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enhanced TGFB1-stimulated SMAD2 phosphorylation, transcriptional responses, and cell migration |