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FLASH GENE
Symbol SH3GLB1 contributors: mct - updated : 23-05-2008
HGNC name SH3-domain GRB2-like endophilin B1
HGNC id 10833
Location 1p22      Physical location : 87.170.256 - 87.213.866
Synonym name
  • SH3-containing protein SH3GLB1
  • Bax interacting factor 1
  • endophilin B1
  • Synonym symbol(s) KIAA0491, CGI-61, BIF1, dJ612B15.2
    DNA
    TYPE functioning gene
    STRUCTURE 43.00 kb     9 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    NYD-SP29 1p22.3 testis development protein NYD-SP29 FLJ13815 1p22.3 hypothetical protein FLJ13815 gm117 1p22.3 gm117 BCL10 1p22 B-cell CLL/lymphoma 10 DDAH1 1p22 dimethylarginine dimethylaminohydrolase 1 CYR61 1p31.p22 cysteine-rich, angiogenic inducer, 61 FLJ20729 1p22.3 hypothetical protein FLJ20729 COL24A1 1p22.3-p22.2 collagen, type XXIV, alpha 1 KIAA1229 1p22.3 KIAA1229 protein CLCA2 1p31-p22 chloride channel, calcium activated, family member 2 CLCA1 1p31-p22 chloride channel, calcium activated, family member 1 CLCA4 1p31-p22 chloride channel, calcium activated, family member 4 CLCA3 1p31-p22 chloride channel, calcium activated, family member 3 SH3GLB1 1p22 SH3-domain GRB2-like endophilin B1 LOC391052 1 similar to dJ612B15.1 (novel protein similar to 60S ribosomal protein L17 (RPL17)) SEP15 1p31 similar to dJ612B15.1 (novel protein similar to 60S ribosomal protein L17 (RPL17)) HS2ST1 1p31.1-p22.1 heparan sulfate 2-O-sulfotransferase 1 LOC388645 1 LOC388645 LMO4 1p22.3 LIM domain only 4
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 6373 40 365 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinesmall intestine  lowly
     intestinelarge intestinecolon lowly
     liver   lowly
    Lymphoid/Immunespleen   lowly
     thymus   lowly
    Nervousbrain   lowly
    Reproductivefemale systemplacenta  highly
    Respiratorylung   lowly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a BAR domain
  • a SH3 domain
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Sh3glb1 (95.9pc)
    homolog to rattus Sh3glb1 (94.8pc)
    homolog to chicken SH3GLB1 (89.5pc)
    Homologene
    FAMILY
  • endophilin related protein family, BCL2 protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • regulator of BAX-mediated signaling pathways for apoptosis
  • may be required for normal outer mitochondrial membrane dynamics
  • may promote membrane fusion
  • functioning as a positive mediator of class III Pi(3) kinase
  • potential activator of autophagy and tumor suppressor
  • CELLULAR PROCESS cell cycle
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • homodimer and heterodimer with SH3GLB2
  • component of a ARNTL protein complex
  • protein complex consisting HTATIP2, SH3GLB1, and ACSL4 that interacts with RAB5a and regulates EGFR endocytosis and signaling
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BAX apoptotic inducer
  • binding to DNM1, HTT, AMPH, BIN1, ARFGAP1
  • interacting with BECN1
  • cell & other
  • binding liposomes and inducing formation of tubules
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    loss of SH3GLB1 may contribute to tumorigenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS