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FLASH GENE
Symbol SH3BGRL3 contributors: - updated : 13-02-2007
HGNC name SH3 domain binding glutamic acid-rich protein like 3
HGNC id 15568
Location 1p35-p34.3      Physical location : 26.606.212 - 26.608.012
Synonym name
  • SH3BGRL3-like protein
  • TNF inhibitory protein
  • Synonym symbol(s) SH3BP-1, TIP-B1
    DNA
    TYPE functioning gene
    STRUCTURE 1.00 kb     3 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     salivary gland   highly
    Endocrinepancreas    
    Reproductivefemale systemovary  highly
    Skin/Tegumentskin appendageshair   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    a SH3-binding, glutamic acid-rich protein motif
    HOMOLOGY
    interspecies homolog to E.coli GRX1
    intraspecies homolog to SH3BGR
    Homologene
    FAMILY thioredoxin superfamily, SH3BGR family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • could act as a modulator of glutaredoxin biological activity
  • may function as a regulator in all-trans retinoic acid-induced pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component EGFP-SH3BGRL3
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS