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FLASH GENE
Symbol SH2D3A contributors: - updated : 25-07-2007
HGNC name SH2 domain containing 3A
HGNC id 16885
Location 19p13.3      Physical location : 6.752.174 - 6.767.523
Synonym symbol(s) NSP1
DNA
TYPE functioning gene
STRUCTURE 15.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon moderately
 mouth   moderately
 pancreas exocrine   moderately
Reproductivefemale systemuteruscervix highly
 female systemplacenta  moderately
Respiratoryrespiratory tracttrachea  moderately
Urinarybladder   highly
cell lineage
cell lines
  • highly expressed in breast cancer cells
  • fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an SH2 domain
  • an exchange factor-like domain binding both Ras GTPases and the scaffolding protein Cas
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to chimpanzee SH2D3A (99.7 pc)
    Homologene
    FAMILY
    CATEGORY adaptor , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may play a role in JNK activation
  • acting as a SH3/SH2 adaptor
  • acting as a guanyl-nucleotide exchange factor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • JNK cascade
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with BCAR1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS