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FLASH GENE
Symbol SGPP2 contributors: - updated : 20-10-2004
HGNC name sphingosine-1-phosphate phosphatase 2
HGNC id 19953
Location 2q36.3      Physical location : 223.289.321 - 223.423.616
Synonym symbol(s) SPP2, FLJ39004
EC.number 3.1.3.-
DNA
TYPE functioning gene
STRUCTURE 136.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinelarge intestinecolon  
 intestinesmall intestine   
Nervousbrain    
Respiratorylung    
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
nine transmembrane segments
HOMOLOGY
interspecies homolog to murine Sgpp2
homolog to rattus LOC81536
Homologene
FAMILY PAP2 superfamily, lipid phosphohydrolase family, SPP subfamily
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
basic FUNCTION
  • phosphohydrolase activity, highly specific to sphingoid base 1-phosphates
  • may be playing a role in attenuating intracellular sphingosine 1 phosphate signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS