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FLASH GENE
Symbol SGO1 contributors: mct/npt/pgu - updated : 21-08-2015
HGNC name shugoshin-like 1 (S. pombe)
HGNC id 25088
Location 3p24.3      Physical location : -
Synonym name
  • shugoshin
  • serologically defined breast cancer antigen NY-BR-85
  • shugoshin 1AB protein
  • shugoshin 1CD protein
  • shugoshin 1EF protein
  • shugoshin 1GH protein
  • shugoshin 1KL protein
  • Synonym symbol(s) NY-BR-85, SGO, SGOL1
    DNA
    TYPE functioning gene
    STRUCTURE 25.64 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1956 59 527 - 2008 18716626
    isoform A1
    9 - 2370 64 561 - 2008 18716626
    isoform A2
    8 - 1200 31 275 - 2008 18716626
    isoform B1
    9 - 1614 35 309 - 2008 18716626
    isoform B2
    7 - 1149 29 258 - 2008 18716626
    isoform C1
    8 - 1563 33 292 - 2008 18716626
    isoform C2
    8 - 1685 - 292 - 2008 18716626
    isoform C4
    7 - 1454 - 215 - 2008 18716626
    isoform D1
    9 - 1736 - 309 - 2008 18716626
    isoform B4
    9 - 2492 - 561 - 2008 18716626
    isoform A4
    - - 4136 - 527 - 2008 18716626
    isoform A3
    - - 3380 - 275 - 2008 18716626
    isoform B3
    - - 3329 - 258 - 2008 18716626
    isoform C3
    - - - - - in human colon cancer 2011 21532624
  • contains an exon-skip of exon 3 that results in a stop codon occurring within exon 4
  • SGOL1-P1 may function as a negative factor to native SGOL1, and that abundant expression of SGOL1-P1 may be responsible for chromosomal instability
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     intestinesmall intestine   
    Reproductivefemale systembreast   
     female systemplacenta   
     male systemprostate   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Blood / hematopoieticplasma   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period
    cell cycle     cell cycle, M
    Text appears in prophase and remains present until metaphase (at protein level)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal coiled-coil domain
  • two functional degradation motifs, a KEN (Lys-Glu-Asn) box and a destruction box (D box)
  • a C-terminal basic region
  • HOMOLOGY
    Homologene
    FAMILY
  • shugoshin family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome,centromere
    text
  • located to centromeres in mitosis
  • colocalizing with PP2A
  • localization at centromeres requires the kinase BUB1
  • SGOL1, which accumulates at the centromeres, in prophase, is not dependent on SKA3
  • basic FUNCTION
  • required for mitotic progression and chromosome segregation
  • protecting, may be by dephosphorylation of cohesin, centromeric cohesin from cleavage (by separase) in meiosis 1, until kinetochores are properly captured by the spindle microtubules
  • sororin (CDCA5) and Shugoshin (SGOL1) protect centromeric cohesion in response to the spindle checkpoint, but prevent the removal of cohesion by a mechanism independent of the APC/C
  • required for maintenance of centromeric cohesion from prophase to the metaphase-anaphase transition
  • implicated in the tension sensing mechanism of the spindle checkpoint by regulating PLK1 kinetochore affinity
  • its recruitment is the important primary role for centromeric heterochromatin in ensuring eukaryotic chromosome segregation
  • protects centromeric sister-chromatid cohesion in early mitosis and, thus, prevents premature sister-chromatid separation
  • protects centromeric sister-chromatid cohesion during prophase and prevents premature sister-chromatid separation
  • key protein in protecting sister chromatids from precocious separation
  • is essential for the suppression of chromosome instability and tumor formation
  • centromeric protein, playing an important role in mitosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specifically associating with PP2A complex containing the B56 subunit
  • interacting with CENPV
  • interacts with Bir1/Survivin and promotes Aurora kinase complex localization to the pericentromeric region, to correct erroneous attachment of kinetochores and thereby enable tension-generating attachment
  • interacting with PPA2 at centromeres where it contribute to protect sister chromatid cohesion in early mitosis and meiosis I
  • collaborates with protein phosphatase 2A (PP2R5E) to protect mitotic cohesin from the prophase dissociation pathway
  • in addition to recruiting PPP2CA to dephosphorylate cohesin and CDCA5, SGO1 physically shields cohesin from WAPL
  • SGO1 binds directly to STAG2 and further shields cohesin from WAPL, protecting sister-chromatid cohesion during mitosis, particularly at centromeres
  • RSF1 regulates SGO1 localization to centromeres through coordinating a crosstalk between histone acetylation and phosphorylation
  • cell & other
    REGULATION
    Other ubiquitinated by the anaphase promoting complex, leading to its degradation
    degraded during the exit from mitosis, and its degradation depends on the anaphase-promoting complex/cyclosome (APC/C)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrantly expressed in various human leukemia cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    might be a promising molecular target for treating individuals with AML (acute myelogenous leukemia)
    ANIMAL & CELL MODELS
  • enhanced chromosome instability observed in Sgol1-deficient mice resulted in an increase in formation of aberrant crypt foci (ACF) and accelerated development of tumors after exposure to azoxymethane (AOM)