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FLASH GENE
Symbol SGK3 contributors: mct - updated : 21-11-2012
HGNC name serum/glucocorticoid regulated kinase family, member 3
HGNC id 10812
Location 8q13.1      Physical location : 67.624.890 - 67.774.255
Synonym name
  • serum/glucocorticoid regulated kinase-like
  • serine/threonine-protein kinase Sgk3
  • cytokine-independent survival kinase
    • Synonym symbol(s) DKFZp781N0293, CISK, SGK2, SGKL
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 149.00 kb     16 Exon(s)
    MAPPING cloned Y linked   status provisional
    Map cen - D8S507 - D8S510 - SGK3 - D8S1797 - D8S543 - D8S279 - qter
    Authors Dai (99)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 splicing 4483 57 496 - 1999 10585774
    differs in the 5' UTR compared to variant 1
    17 - 4206 57 496 - 1999 10585774
    16 splicing 4110 53 464 - 1999 10585774
    lacking an alternate in-frame exon
    16 - 4563 57 496 - 1999 10585774
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • PX (phox homology) domain
  • protein kinase C-terminal domain
    • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Sgk3
    intraspecies homolog to SGK1
    Homologene
    FAMILY
  • ser/thr protein kinase family, AGC family of kinases
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    basic FUNCTION
  • playing an important role in activating certain potassium, sodium, and chloride channels
  • may be involved in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion
  • phosphorylates FLII and activates nuclear receptor transcription, suggesting a new cell survival signaling pathway mediated by PI 3-kinase and GSK3
  • SGK3 and AKT2 both appear to play potentially important roles in postnatal hair follicle morphogenesis
  • SGK1/SGK3 are novel potent stimulators of SLC6A19 and may thus participate in the regulation of neutral amino acid transport
  • has a subtle but significant role in the regulation of renal tubular phosphate transport and bone density
  • plays a previously unappreciated role in glucose homeostasis, likely through direct effects within beta-cells, to stimulate proliferation and insulin release, at least in part by controlling the expression and activity of CTNNB
  • functions downstream of the PI 3-kinase cascade and shares molecular and biochemical similarities with AKT
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with NEDD4 and NEDD4L
  • regulating BSND and participating in the regulation of transport in kidney and inner ear
  • interacting with SGK and SLC6A8 (increase SLC6A8 activity by increasing the maximal transport rate of the carrier)
  • SGK1, SGK2, SGK3 participate in the regulation of KCNE1-dependent transport and excitability
  • FLII is a substrate of SGK3 that functions downstream of PI 3-kinase and SGK3 can associate with FLII and phosphorylate FLII at residues Ser(436) and Thr(818)
  • SGK1, SGK2, SGK3 are novel potent stimulators of SLC6A19 and may thus participate in the regulation of neutral amino acid transport
  • novel endosomal kinase that acutely regulates SLC9A3 in a PI3K-dependent mechanism
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking SGK3 have abnormal follicle cycling, which begins shortly after birth and ameliorates substantially with age; however, this developmental abnormality is not recapitulated in mice lacking closely related kinases Akt1, Akt2, or Akt3