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FLASH GENE
Symbol SGK2 contributors: mct - updated : 05-01-2013
HGNC name serum/glucocorticoid regulated kinase 2
HGNC id 13900
Location 20q13.12      Physical location : 42.187.685 - 42.214.272
Synonym name serine/threonine-protein kinase Sgk2
Synonym symbol(s) dJ138B7.2 , H-SGK2
EC.number 2.7.11.1
DNA
TYPE functioning gene
STRUCTURE 26.60 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 1913 41 367 - 1999 10548550
13 - 1942 - 367 - 1999 10548550
12 - 2146 47.5 427 - 1999 10548550
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Urinarykidneytubuleconvoluted tubuleproximal tubule  Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • protein kinase superfamily
  • AGC Ser/Thr protein kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • may play a previously unrecognized role in the control of transtubular Na(+) transport through SLC9A3 in the proximal tubule
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SGK1, SGK2, SGK3 participate in the regulation of KCNE1-dependent transport and excitability
  • SGK1, SGK2, SGK3 are novel potent stimulators of SLC6A19 and may thus participate in the regulation of neutral amino acid transport
  • interaction with TP53 and PAK3 (loss of TP53 together with either SGK2 or PAK3 loss leads to cell death)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveuterus
    SGK2 and PAK3 may represent targets for TP53-specific cervical carcinomas drug development
    ANIMAL & CELL MODELS