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FLASH GENE
Symbol SGCZ contributors: - updated : 04-01-2006
HGNC name sarcoglycan zeta
HGNC id 14075
Location 8p22      Physical location : 13.947.373 - 15.095.792
Synonym symbol(s) ZSG1
DNA
TYPE functioning gene
STRUCTURE 465.00 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularsmooth   
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a short intra-cellular domain
  • a single transmembrane region
  • a large extra-cellular domain containing a carboxyl-terminal cluster with several conserved cysteine residues
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Sgcd
    homolog to chimpanzee LOC472703
    intraspecies homolog to SGCG
    homolog to SGCD
    Homologene
    FAMILY sarcoglycan beta/delta/gamma/zeta family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing a role in mediating muscular membrane stability of striated muscle
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS locomotion
    PATHWAY
    metabolism
    signaling
    a component component of the sarcoglycan complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein SGCB
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    muscular dystrophy, limb-girdle, type 2C
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS