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FLASH GENE
Symbol SFXN4 contributors: mct - updated : 12-12-2013
HGNC name sideroflexin 4
HGNC id 16088
Corresponding disease
MCYTAM macrocytic anemia with mitochondriopathy
Location 10q26.11      Physical location : 120.900.430 - 120.925.204
Synonym name breast cancer resistance marker 1
Synonym symbol(s) BCRM1
DNA
TYPE functioning gene
STRUCTURE 24.80 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
PNLIPRP1 10q26.12 pancreatic lipase-related protein 1 PNLIPRP2 10q26.12 pancreatic lipase-related protein 2 MGC33547 10q26.12 hypothetical protein MGC33547 HSPA12A  heat shock 70kDa protein 12A LOC387712 10 similar to RIKEN cDNA 6430537H07 gene KIAA1598 10q26.12 KIAA1598 protein LOC387713 10 similar to ventral anterior homeobox 1 TRIK 10q26.12 TWIK-related spinal cord K+ channe SLC18A2 10q25 solute carrier family 18 (vesicular monoamine), member 2 LOC118987 10q26.12 hypothetical protein LOC118987 LOC387714 10 LOC387714 EMX2 10q26.1 empty spiracles homolog 2 (Drosophila) Rab11-FIP2 10q26.12 KIAA0941 protein C10orf5 10q26.12 chromosome 10 open reading frame 5 FLJ13188 10q26.12 hypothetical protein FLJ13188 GPR10 10q25.3-q26 G protein-coupled receptor 10 LOC390007 10 similar to Mitochondrial import receptor subunit TOM22 homolog (Translocase of outer membrane 22 kDa subunit homolog) (hTom22) (1C9-2) C10orf46 10q26.12-q26.13 chromosome 10 open reading frame 46 LOC88066 10q26.13 similar to 60S ribosomal protein L17 (L23) NANOS1 10q26.13 nanos homolog 1 (Drosophila) EIF3S10 10q26 eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa SFXN4 10q26.12 sideroflexin 4 PRDX3 10q25-q26 peroxiredoxin 3 GPRK5 10q24-qter G protein-coupled receptor kinase 5 RGS10 10q25 regulator of G-protein signalling 10 TIAL1 10q26.11 TIA1 cytotoxic granule-associated RNA binding protein-like 1 LOC119563 10q26.13 similar to 40S ribosomal protein S8 BAG3 10q25.2-q26.2 BCL2-associated athanogene 3 LOC93202 10q26.13 thioredoxin 1 pseudogene 2 INPP5F 10q26.13 inositol polyphosphate-5-phosphatase F FLJ13081 10q26.13 hypothetical protein FLJ13081 SEC23IP 10q25-q26 SEC23 interacting protein LOC338570 10q26.13 similar to alpha NAC/1.9.2. protein LOC196051 10q26.13 hypothetical protein LOC196051 WDR11 10q26 WD repeat domain 11 FGFR2 10q26 fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1492 - 305 - 2003 14756423
14 - 1400 - 337 - 2003 14756423
  • SFXN4 I1
  • - - 1400 37 337 placenta 2003 14756423
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • tricarboxylate/iron carrier motif
  • conserved predicted five-transmembrane-domains structure
  • HOMOLOGY
    interspecies homolog to to mouse sideroflexin4
    Homologene
    FAMILY sideroflexin family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    text localizes to the mitochondrial inner membrane (PMID;
    basic FUNCTION
  • having cation transporter activity
  • required for mitochondrial homeostasis and hematopoiesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCYTAM
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS