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FLASH GENE
Symbol SFXN2 contributors: - updated : 09-10-2007
HGNC name sideroflexin 2
HGNC id 16086
Location 10q24.32      Physical location : 104.474.297 - 104.498.946
DNA
TYPE functioning gene
STRUCTURE 24.00 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
NPM3 10q24.31 nucleophosmin/nucleoplasmin, 3 MGEA5 10q24.1-q24.3 meningioma expressed antigen 5 (hyaluronidase) KCNIP2 10q24 Kv channel interacting protein 2 FLJ13114 10q24.32 hypothetical protein FLJ13114 HPS6 10q24.32 hypothetical protein FLJ13114 LDB1 10q24-q25 LIM domain binding 1 PRC 10q24.32 PGC-1 related co-activator NOLC1 10q22-q25 nucleolar and coiled-body phosphoprotein 1 ELOVL3 10q24.32 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 PITX3 10q25 paired-like homeodomain transcription factor 3 GBF1 10q24 golgi-specific brefeldin A resistance factor 1 NFKB2 10q24 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) PSD 10q24 pleckstrin and Sec7 domain protein MGC11279 10q24.32 hypothetical protein MGC11279 MGC2491 FLJ14280 10q24.32 hypothetical protein FLJ14280 FLJ22529 10q24.32-q24.33 hypothetical protein FLJ22529 ACTR1A 10q24 ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) SUFU 10q24.32 suppressor of fused homolog (Drosophila) TRIM8 10q24.3 tripartite motif-containing 8 ARL3 10q24.1 ADP-ribosylation factor-like 3 SFXN2 10q24.32 sideroflexin 2 C10orf26 10q24.33 chromosome 10 open reading frame 26 CYP17A1 10q24.3 cytochrome P450, family 17, subfamily A, polypeptide 1 LOC390000 10 similar to Tebp-pending-prov protein C10orf32 10q24.33 chromosome 10 open reading frame 32 CYT19 10q24.33 Cyt19 protein CNNM2 10q24.32 cyclin M2 NT5C2 10q24.32 5'-nucleotidase, cytosolic II LOC90470 10q24.33 similar to Ribulose-phosphate 3-epimerase (Ribulose-5-phosphate-3-epimerase) (HUSSY-17) INA 10q24.33 internexin neuronal intermediate filament protein, alpha RNF134 10q24.33 ring finger protein 134 TAF5 10q24 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa MGC14697 10q24.33 upregulated during skeletal muscle growth 5 LOC51063 10pter-q26.12 hypothetical protein LOC51063 LOC119395 10q24.33 hypothetical protein LOC119395 NEURL 10q25.1 neuralized-like (Drosophila)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveesophagus   moderately
 liver    
Endocrinepancreas    
 parathyroid   highly
 thyroid   moderately
Reproductivefemale systembreastmammary gland  
 male systemprostate   
Urinarykidney   predominantly
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • tricarboxylate/iron carrier motif
  • HOMOLOGY
    interspecies homolog to dog SFXN2 (94.4 pc)
    homolog to chimpanzee SFXN2 (99.7 pc)
    homolog to murine Sfxn2 (89.1 pc)
    homolog to chicken SFXN2 (74.7 pc)
    Homologene
    FAMILY
  • sideroflexin family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    basic FUNCTION
  • involved in iron ion transport
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • iron ion transport
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Fe2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS