Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

SFTPA2

contributors: mct - updated : 15-10-2019

HGNC name	surfactant, pulmonary-associated protein A2
HGNC id	10799

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	IPF1 pulmonary fibrosis, idiopathic 1
Location	10q22.3      Physical location : 81.315.608 - 81.320.163
Synonym name	35 kDa pulmonary surfactant-associated protein
	alveolar proteinosis protein
	collectin 5
Synonym symbol(s)	SP-A2, COLEC5, SP-2A beta, SP-A1, SP-A1 beta, SPAII, PSAP, PSP-A, PSPA, SFTP1B, FLJ79091, FLJ93678, MGC133169, MGC133366, MGC189714

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	clustered with SFTPA1
STRUCTURE	4.61 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence

Promoter (TATA box)

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

text	five different classes of transcripts alternatively spliced at their 5' end (McCormick)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001098668 6 - 2201 NP_001092138 - 248 - 1992 1372511 NM_001320813 6 - 2204 NP_001307742 - 248 - 1992 1372511 NM_001320814 5 - 2341 NP_001307743 - 258 - 1992 1372511

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Respiratory lung

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	mid gestation fetal lung

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one c-type lectin family domain
	one collagenous domain

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

collectin family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION	important role in innate immunity
	involved in host defense, also involved in the surface tension lowering ability of pulmonary surfactant
	SFTPA1, SFTPA2 plays a key role in innate lung host defense, in surfactant-related functions, and in parturition
	innate host defense molecules, surfactant protein A1 (SFTPA1), and SFTPA2 differentially affect the function and proteome of the alveolar macrophages

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

a complex with SFTPA1

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

IPF1

Susceptibility

to respiratory distress in very premature infant to tuberculosis

Variant & Polymorphism SNP , other	6A2 overexpressed
	355C and 751C increasing the risk of tuberculosis in Ethiopia

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS