basic FUNCTION
| likely involved in WNT binding |
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WNT-frizzled proteins signaling pathways |
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may regulate hematopoietic stem cells ![](pubmed.jpg) |
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involved in embryonic development as well as pathological conditions including bone and myocardial disorders and cancer ![](pubmed.jpg) |
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having role as an enhancer of Wnt/beta-catenin signaling, a result with biological impact for both normal development and diverse pathologies such as tumorigenesis ![](pubmed.jpg) |
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augments canonical Wnt3a/beta-catenin signaling at the level of its cell surface receptor ![](pubmed.jpg) |
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potential enhancer of canonical Wnt signaling and therefore has a possible role as a paracrine/autocrine positive modulator of this key cellular signal transduction pathway ![](pubmed.jpg) |
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SFRP1, SFRP2 can either promote or suppress Wnt/CTNNB1 signaling, depending on cellular context, concentration and most likely the expression pattern of Fzd receptors ![](pubmed.jpg) |
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SFRP1, SFRP2 play a role in lens development, at least in part, by regulating aspects of WNT/CTNNB1 signaling in lens epithelial cells ![](pubmed.jpg) |
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is a key profibrotic cytokine in the heart ![](pubmed.jpg) |
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SFRP2 enhanced osteo-/dentinogenic differentiation via Osterix, a key transcription factor in stem cells derived from apical papillae (SCAPs) ![](pubmed.jpg) |