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FLASH GENE
Symbol SFRP2 contributors: mct/pgu - updated : 16-09-2016
HGNC name secreted frizzled-related protein 2
HGNC id 10777
Location 4q31.3      Physical location : 154.701.741 - 154.710.228
Synonym name
  • secreted apoptosis releted protein 1
  • frizzled-related protein 2
    • Synonym symbol(s) FZDS2, SARP1, FRP2, SDF5
    DNA
    TYPE functioning gene
    STRUCTURE 8.49 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2005 31.5 295 - 1997 9391078
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     intestinesmall intestine   
    Visualeyelens    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsensoryvisualinner nuclear layer 
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skeletonosteoblast
    Visualepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a frizzled-like cysteine-rich domain
  • a conserved hydrophilic carboxyterminal domain
    • HOMOLOGY
    interspecies homolog to Drosophila frizzled polarity
    homolog to murine Sfrp 2
    Homologene
    FAMILY
  • secreted frizzled-related protein (sFRP) family
    • CATEGORY secretory , signaling
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    basic FUNCTION
  • likely involved in WNT binding
  • WNT-frizzled proteins signaling pathways
  • may regulate hematopoietic stem cells
  • involved in embryonic development as well as pathological conditions including bone and myocardial disorders and cancer
  • having role as an enhancer of Wnt/beta-catenin signaling, a result with biological impact for both normal development and diverse pathologies such as tumorigenesis
  • augments canonical Wnt3a/beta-catenin signaling at the level of its cell surface receptor
  • potential enhancer of canonical Wnt signaling and therefore has a possible role as a paracrine/autocrine positive modulator of this key cellular signal transduction pathway
  • SFRP1, SFRP2 can either promote or suppress Wnt/CTNNB1 signaling, depending on cellular context, concentration and most likely the expression pattern of Fzd receptors
  • SFRP1, SFRP2 play a role in lens development, at least in part, by regulating aspects of WNT/CTNNB1 signaling in lens epithelial cells
  • is a key profibrotic cytokine in the heart
  • SFRP2 enhanced osteo-/dentinogenic differentiation via Osterix, a key transcription factor in stem cells derived from apical papillae (SCAPs)
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulating the intracellular level of beta catenin
  • SFRP1, SFRP2 inhibits the ADAM10 metalloprotease, which might have important implications in pathological events, including cancer and Alzheimer disease
  • HR repressed the expression of Wnt inhibitors, including SOSTDC1, DKKL1, SFRP1, and SFRP2
  • SREBPF1 regulated transcriptional activation of the SFRP2 gene in chondrogenic cells
  • FRP2 may promote cardiac fibrocalcification through coordinate activation of tolloid-like metalloproteinases and ALPL
  • silencing KDM2A, a histone demethylase and BCL6 co-repressor, derepressed SFRP2 transcription by increasing histone H3K4 and H3K36 methylation at the SFRP2 promoter
    • cell & other
    REGULATION
    repressed by DKK1 that negates all SFRP2 effects on Wnt3a signaling
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in retinitis pigmentosa
    tumoral       loss of function
    in colorectal cancer
    tumoral     --over  
    repressed Wnt target genes and induced changes in the expression of numerous genes related to proliferation, growth and apoptosis in gastric cancer cells
    tumoral     --low  
    silencing leads to oncogenic activation of the Wnt pathway and contributes to cervical cancer progression through the epithelial mesenchymal transition program
    tumoral     --low  
    by hypermethylation in primary hepatocellular carcinoma
    constitutional       loss of function
    of SFRP1 and SFRP2, two postulated Wnt antagonists, perturbs retinal neurogenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • methylated SFRP2 and TMEFF2 detected in 94.2 p100, and 71.2 p100 of colorecal cancer (CRC), and methylation testing of fecal DNA may be a simple and promising non-invasive screening method for CRC and precancerous lesions
    • Therapy target
    ANIMAL & CELL MODELS