basic FUNCTION
| late splicing factor, repressing the transcription of multiple oncogenic genes |
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acting as a progesterone receptor corepressor and contributing to the functional withdrawal of progesterone and the initiation of labor |
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repressor which interacts with SIN3A and mediates silencing through the recruitment of HDACs to the receptor DNA binding domains |
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with PSPC1 and NONO, may cooperatively regulate androgen receptor-mediated gene transcription |
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may have dual functions in homologous recombination and RNA processing |
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core paraspeckle protein |
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critical to the control of gene expression through the nuclear retention of RNA containing double-stranded RNA regions that have been subject to adenosine-to-inosine editing |
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have homologous recombination and non-homologous end joining related activities and also to bind and modulate the function of RAD51 |
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SFPQ/NONO heterodimer was previously found to enhance DNA strand break rejoining |
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have multiple functions in RNA processing, transcription and DNA repair by mitotic recombination |
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may function as an activator for the meiosis-specific recombinase DMC1 in higher eukaryotes |
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involvement of NONO and SFPQ in DNA double-strand break repair (DSB) and radioresistance |
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important role of NONO, PSPC1, SFPQ within the circadian oscillator |
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overlapping or redundant roles of NONO, PSPC1, SFPQ as transcriptional cofactors at circadian clock-regulated genes |
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is an RNA-binding proteins (RBPs) that binds and regulates multiple mRNAs in dorsal root ganglion sensory neurons and thereby promotes neurotrophin-dependent axonal viability |
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acts in nuclei, cytoplasm and axons to regulate functionally related mRNAs essential for axon survival |
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plays an important role regulating proliferation and migration during the development of the cerebral cortex |
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SFPQ is targeted for proteolysis within the nucleus by viral proteinase 3CD/3C, and a fragment of SFPQ was shown to migrate to the cytoplasm at mid-to-late times of infection |
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SFPQ, a proline and glutamine rich splicing factor that participates in diverse molecular functions including paraspeckle formation, microRNA synthesis and transcription regulation, is known to regulate host innate immune response to viruses |