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FLASH GENE
Symbol SFI1 contributors: mct/npt - updated : 10-07-2008
HGNC name Sfi1 homolog, spindle assembly associated (yeast)
HGNC id 8999
Location 22q12.2      Physical location : 31.892.260 - 32.014.533
Synonym name
  • phosphatidylserine decarboxylase proenzyme
  • phosphatidylserine decarboxylase alpha chain
  • phosphatidylserine decarboxylase beta chain
  • Synonym symbol(s) PSSC, dJ858B16.2, PSDC, PISD, hSfi1p, MGC57874, MGC131712, MGC150663, KIAA0542
    EC.number 4.1.1.65
    DNA
    TYPE functioning gene
    SPECIAL FEATURE gene in gene
    text SFI1 and PISD
    STRUCTURE 122.00 kb     33 Exon(s)
    regulatory sequence Binding site
    motif repetitive sequence
    text structure 23 repeats, each of 23 amino acids, separated by 10 residue linkers
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2693 - 375 - Forbes (2007)
    - - 4302 - 1242 - Kilmartin (2003)
    - - 4209 144 1211 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
     thyroid   highly
    Lymphoid/Immunethymus   highly
    Reproductivefemale systemplacenta  highly
     female systemuteruscervix highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • phosphatidylserine decarboxylase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    basic FUNCTION
  • cofactor pyridoxal phosphatidylserine pyruvate
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds centrin in the repeat region, showing that this centrin-binding motif is conserved
  • interacting with centrin 2 (CETN2), role of centrin-SFI1 interactions in the dynamic structure of centrosome-associated contractile fibers
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS