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FLASH GENE
Symbol SF3B3 contributors: mct - updated : 20-02-2018
HGNC name splicing factor 3b, subunit 3, 130kDa
HGNC id 10770
Location 16q22.1      Physical location : 70.557.690 - 70.611.570
Synonym name
  • spliceosome-associated protein 130
  • pre-mRNA splicing factor SF3b, 130 kDa
  • Synonym symbol(s) RSE1, SAP130, SF3b130, STAF130, KIAA0017
    DNA
    TYPE functioning gene
    STRUCTURE 53.88 kb     27 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ12331 16q22.1 hypothetical protein FLJ12331 HAS3 16q22.1 hyaluronan synthase 3 FLJ20400 16q22.1 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) CIRH1A 16q22.1 cirrhosis, autosomal recessive 1A (cirhin) SNTB2 16q22-q23 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) VPS4A 16q23.1 vacuolar protein sorting 4A (yeast) COG8 16q22.1 component of oligomeric golgi complex 8 PDF 16q22.1 peptide deformylase-like protein CGI-37 16q22.1 comparative gene identification transcript 37 MGC23911 16q22.1 hypothetical protein MGC23911 TERF2 16q22.1 telomeric repeat binding factor 2 CYB5-M 16q22.1 cytochrome b5 outer mitochondrial membrane precursor NFAT5 16q22.1 nuclear factor of activated T-cells 5, tonicity-responsive NQO1 16q12-q22 NAD(P)H dehydrogenase, quinone 1 NOB1P 16q22.3 likely ortholog of mouse nin one binding protein LOC388285 16 hypothetical gene supported by U89867; NM_007363 WWP2 16q22.1 Nedd-4-like ubiquitin-protein ligase LOC348174 16q22.1 secretory protein LOC348174 LOC390737 16 similar to MGC9515 protein LOC283970 16q22.1 hypothetical protein LOC283970 PDPR 16q22.1 pyruvate dehydrogenase phosphatase regulatory subunit MGC34761 16q22.1 hypothetical protein MGC34761 LOC388286 16 hypothetical gene supported by AF395444; NM_014006 MTR3 16q22.1 homolog of yeast mRNA transport regulator 3 AARS 16q22.1 alanyl-tRNA synthetase DDX19 16q22.1 DEAD (Asp-Glu-Ala-As) box polypeptide 19 FLJ11126 16q22.1 hypothetical protein FLJ11126 SIAT4B 16q22.3 sialyltransferase 4B (beta-galactoside alpha-2,3-sialyltransferase) FUK 16q22.1 fucokinase COG4 16q22.3 component of oligomeric golgi complex 4 SF3B3 16q22.1 splicing factor 3b, subunit 3, 130kDa MGC34647 16q22.1 hypothetical protein MGC34647 LOC92154 16q22.1 hypothetical protein BC002770 FLJ10305 16q22.1 hypothetical protein FLJ10305 HYDIN 16q22.2 hydrocephalus inducing LOC388287 16 similar to hydrocephalus-inducing protein FLJ14665 16q22.2 hypothetical protein FLJ14665 DKFZp434L0850 16q22.2 hypothetical protein DKFZp434L0850 FLJ11171 16q22.2 hypothetical protein FLJ11171 LOC388288 16 similar to hypothetical protein (L1H 3 region) - human CALB2 16q22.2 calbindin 2, 29kDa (calretinin) ZNF23 16q22.2 zinc finger protein 23 (KOX 16) LOC390738 16 similar to mKIAA1261 protein ZNF19 16q23.1 zinc finger protein 19 (KOX 12) CHST4 16q23.1 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 TAT 16q22.1 tyrosine aminotransferase LOC91862 16q22.2 similar to RIKEN cDNA 1810006A16 gene KIAA0931 16q23.1 similar to RIKEN cDNA 1810006A16 gene AP1G1 16q23 adaptor-related protein complex 1, gamma 1 subunit LOC342371 16q22.2 similar to Ataxin-1 (Spinocerebellar ataxia type 1 protein homolog) LOC55565 16q22.2 hypothetical protein LOC55565 KIAA0174 16q23.1 hypothetical protein LOC55565 PKD1L3 16q22.2 polycystic kidney disease 1-like 3 DHODH 16q22 dihydroorotate dehydrogenase HP 16q22.2 haptoglobin HPR 16q22.2 haptoglobin-related protein FLJ20511 16q22.2 hypothetical protein FLJ20511 DHX38 16q21-q22.3 DEAH (Asp-Glu-Ala-His) box polypeptide 38 PMFBP1 16q23.1 polyamine modulated factor 1 binding protein 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    26 - 9736 - 1217 - 2002 12234937
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text umbilical vein
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to yeast S.cerevisiae sap130
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text
  • localizes in both the nucleus and the cytoplasm
  • basic FUNCTION
  • required for the assembly of the spliceosomal complex
  • is a cullin binding protein that is likely involved in the NEDD8 pathway
  • role of SF3B3 in endocrine resistance and prognosis in ER-positive breast cancer
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the "a" complex in the spliceosome assembly pathway
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • U2SnRNP,U11/U12SnRNP associated splice protein
  • associating with other SF3B proteins, interacting with SAP155, (SF3B1)
  • may likely link Cullin-RING ubiquitin E3 ligases (CRLs) mediated ubiquitination to gene expression
  • SF3B3 binds to several Cullin proteins
  • its overexpression reduces the binding of adaptor protein SKP1 and substrate receptor SKP2 to CUL1, whereas it has no effect on CAND1 binding to CUL1
  • MCM7 binds SF3B3, and the binding motif is located in the N terminus (amino acids 221-248) of MCM7
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS