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FLASH GENE
Symbol SF3B2 contributors: mct/npt - updated : 17/09/2008
HGNC name splicing factor 3b, subunit 2, 145kDa
HGNC id 10769
Location 11q13.1      Physical location : 65.819.815 - 65.836.382
Synonym name
  • pre-mRNA splicing factor SF3b 145 kDa subunit
  • spliceosome associated protein 145
  • Synonym symbol(s) SAP145, SF3B145, SF3b1, SF3b150
    DNA
    TYPE functioning gene
    STRUCTURE 16.56 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 2902 - 895 - Ewing (2007)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Nervousspinal cord   highly
    Reproductivemale systemprostate  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a proline-rich N terminus
  • a CUS1 domain
  • a glutamate rich stretch in the C-terminus
  • lacking RNA binding motifs
  • HOMOLOGY
    interspecies ortholog to yeast S.cerevisiae cus1
    ortholog to C.elegans zk.632.1
    Homologene
    FAMILY
  • SnRNP associated proteins family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • required for the assembly of spliceosomal complex
  • playing with SF3B4 roles in cell cycle progression
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the "a" complex in the spliceosome assembly pathway
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • U2SnRNP, U11/U12SnRNP associated splice protein
  • associating with other SF3b proteins, interacting directly with SAP49(SF3B4)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS