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FLASH GENE
Symbol SF3A2 contributors: - updated : 24-05-2006
HGNC name splicing factor 3a, subunit 2, 66kDa
HGNC id 10766
Location 19p13.3      Physical location : 2.236.815 - 2.248.677
Synonym name spliceosome associated protein (SAP62)
Synonym symbol(s) SAP62, SF3A66, PRP11, PRPF11
DNA
TYPE functioning gene
STRUCTURE 11.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
regionally located contigous to the AMH gene
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemuteruscervix highly
Skin/Tegumentskin   highly
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a proline rich short consensus repeats
  • a single zinc finger domain
  • mono polymer heteromer , trimer , complex
    HOMOLOGY
    interspecies homolog to yeast splicing factor PRP11
    ortholog to yeast S.cerevisiae PRP11
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • converting the U2 snRNP to its active form
  • can induce neurite extension, and having functions in the regulation of cell morphology
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • spliceosome component of "a" complex of three subunits (SF3A1, SF3A2, SF3A3) required for the binding of U2 to the branch point in pre-mRNA sequence
  • INTERACTION
    DNA
    RNA
    small molecule
    protein binds to beta-tubulin, and also to microtubules, with high affinity (it is a novel microtubule-associated protein)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS