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FLASH GENE
Symbol SF3A1 contributors: npt/ - updated : 12-02-2007
HGNC name splicing factor 3a, subunit 1, 120kDa
HGNC id 10765
Location 22q12.1      Physical location : 30.727.978 - 30.752.913
Synonym name
  • spliceosome associated protein 114
  • pre-mRNA processing 21
  • Synonym symbol(s) SF3a120, SAP114, PRPF21, Prp21
    DNA
    TYPE functioning gene
    STRUCTURE 24.94 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - ADORA2A - TIMP3 - [D22S1144 - SLC5A1 - NF2 NF2 - TCN2 TCN2 - D22S280 ] - qter
    Authors Gene Map (98),LDB (99)
    Text [SF3A1 ]
    Physical map
    NIPSNAP1 22q12.2 nipsnap homolog 1 (C. elegans) NF2 22q12.2 neurofibromin 2 (bilateral acoustic neuroma) CABP7 22q12.2 calcium binding protein 7 LOC55954 22cen-q12.3 hypothetical protein LOC55954 HSPC051 22cen-q12.3 ubiquinol-cytochrome c reductase complex (7.2 kD) ASC1p100 22q12.1 ASC-1 complex subunit P100 MTMR3 22q12.2 myotubularin related protein 3 LOC391326 22 similar to h2-calponin MGC26710 22q12.2 hypothetical protein MGC26710 LIF 22q12.2 leukemia inhibitory factor (cholinergic differentiation factor) OSM 22q12.2 oncostatin M TBC1D10 22q12.1-qter TBC1 domain family, member 10 SF3A1 22q12.1 splicing factor 3a, subunit 1, 120kDa LOC388891 22 similar to hypothetical protein 4930562D19 LOC200312 22q12.2 similar to RIKEN cDNA 0610009J22 SEC14L2 22q12.2 SEC14-like 2 (S. cerevisiae) HSPC242 22q hypothetical protein HSPC242 LOC391327 22 similar to solute carrier family 39 (zinc transporter), member 1; zinc-iron regulated transporter-like gene; solute carrier family 39 (zinc transporter), member 3; zinc/iron regulated transporter-like SEC14L3 22q12.2 SEC14-like 3 (S. cerevisiae) LOC376844 SEC14L4 22q12.1 SEC14-like 4 (S. cerevisiae) PTPNS1L 22q12.2 protein tyrosine phosphatase, non-receptor type substrate 1-like CST 22q12.2 protein tyrosine phosphatase, non-receptor type substrate 1-like PES1 22q12.2 pescadillo homolog 1, containing BRCT domain (zebrafish) TCN2 22q12.2 transcobalamin II; macrocytic anemia SLC35E4 22q12.2 solute carrier family 35, member E4 LOC391328 22 similar to tum- transplantation antigen P198 DUSP18 22q12.1 dual specificity phosphatase 18 OSBP2 22q12.2 oxysterol binding protein 2 FLJ35801 22q12.2 hypothetical protein FLJ35801 ZCWCC1 22q12.2 zinc finger, CW-type with coiled-coil domain 1 FLJ20618 22q12.2 hypothetical protein FLJ20618
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 4941 81.5 728 - -
    - - 5136 88.7 793 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal SURP module identified in the essential splicing factor PRP21 of S cerevisiae and binding to SF3A3
  • a C terminal domain binding to SF3A2
  • HOMOLOGY
    interspecies ortholog to yeast S.cerevisiae PRP21
    ortholog to Drosophila alternative regulator suppressor-of-white-apricot
    homolog to C.elegans four proteins
    homolog to mammals
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • converting U2 SnRNP in its active form
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • spliceosome
  • component of "a" complex of three subunits SFRA1, SFRA2, SFRA3, anchoring to the branch point in pre-mRNA seqence
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SnRNP-associated splicing activities, activating U2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS