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FLASH GENE
Symbol SF3A1 contributors: npt/ - updated : 12-02-2007
HGNC name splicing factor 3a, subunit 1, 120kDa
HGNC id 10765
Location 22q12.1      Physical location : 30.727.978 - 30.752.913
Synonym name
  • spliceosome associated protein 114
  • pre-mRNA processing 21
  • Synonym symbol(s) SF3a120, SAP114, PRPF21, Prp21
    DNA
    TYPE functioning gene
    STRUCTURE 24.94 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - ADORA2A - TIMP3 - [D22S1144 - SLC5A1 - NF2 NF2 - TCN2 TCN2 - D22S280 ] - qter
    Authors Gene Map (98),LDB (99)
    Text [SF3A1 ]
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 4941 81.5 728 - -
    - - 5136 88.7 793 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal SURP module identified in the essential splicing factor PRP21 of S cerevisiae and binding to SF3A3
  • a C terminal domain binding to SF3A2
  • HOMOLOGY
    interspecies ortholog to yeast S.cerevisiae PRP21
    ortholog to Drosophila alternative regulator suppressor-of-white-apricot
    homolog to C.elegans four proteins
    homolog to mammals
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • converting U2 SnRNP in its active form
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • spliceosome
  • component of "a" complex of three subunits SFRA1, SFRA2, SFRA3, anchoring to the branch point in pre-mRNA seqence
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SnRNP-associated splicing activities, activating U2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS