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FLASH GENE
Symbol SF1 contributors: mct - updated : 16-10-2018
HGNC name splicing factor 1
HGNC id 12950
Location 11q13.1      Physical location : 64.532.075 - 64.546.316
Synonym name
  • DNA segment, single copy, probe cCI11-367
  • zinc finger protein 162
  • mammalian branch point-binding protein mBBP
  • transcription factor ZFM1
  • Zinc finger motif-1
  • Synonym symbol(s) D11S636, ZFM1, ZNF162, BBP, MBBP, ZCCHC25
    DNA
    TYPE functioning gene
    STRUCTURE 14.24 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    RPS6KA4 11q11-q13 ribosomal protein S6 kinase, 90kDa, polypeptide 4 LOC387777 11 LOC387777 FLJ37045 11q13.1 hypothetical protein FLJ37045 SLC22A11 11q13.1 solute carrier family 22 (organic anion/cation transporter), member 11 SLC22A12 11q13.1 solute carrier family 22 (organic anion/cation transporter), member 12 NRXN2 11q13.2 neurexin 2 RASGRP2 11q13 RAS guanyl releasing protein 2 (calcium and DAG-regulated) PYGM 11q13.2 phosphorylase, glycogen; muscle (McArdle syndrome, glycogen storage disease type V) SF1 11q13.2 splicing factor 1 MAP4K2 11q13 mitogen-activated protein kinase kinase kinase kinase 2 MEN1 11q13.2 multiple endocrine neoplasia I HSMDPKIN 11q13 multiple endocrine neoplasia I EHD1 11q13 EH-domain containing 1 KIAA0404 11q13.3-q13.5 EH-domain containing 1 PPP2R5B 11q13 protein phosphatase 2, regulatory subunit B (B56), beta isoform GPHA2 11q13.1 glycoprotein hormone alpha 2 LOC283129 11q13.1 hypothetical protein LOC283129 LOC116071 11q13.1 hypothetical protein BC012330 SNX15 11q12 sorting nexin 15 ARL2 11q13 ADP-ribosylation factor-like 2 LOC390210 11 similar to Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1) (eEF1A-1) (Elongation factor Tu) (EF-Tu) HSU79266 11q13.1 protein predicted by clone 23627 NAALADL1 11q12 N-acetylated alpha-linked acidic dipeptidase-like 1 LOC256676 11q13.1 hypothetical LOC256676 CDCA5 11q12.1 cell division cycle associated 5 ZFPL1 11q13 zinc finger protein-like 1 C11orf2 11q13 chromosome 11 open reading frame2 TM7SF2 11q13 transmembrane 7 superfamily member 2 C11orf5 11q13 chromosome 11 open reading frame 5 FAU 11q12-q13.1 Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived); ribosomal protein S30 MRPL49 11q13 mitochondrial ribosomal protein L49 HRD1 11q13 HRD1 protein
    regionally located at the MEN1 locus
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 splicing 2953 - 571 - 2015 26420826
  • 2 exons
  • 13 splicing 2949 59.6 548 - 2015 26420826
  • 13 exons
  • 13 splicing 3586 68.2 639 - 2015 26420826
  • 13 exons
  • 14 splicing 3154 68.5 638 - 2015 26420826
  • 14 exons
  • 13 - 2946 - 673 - 2015 26420826
    13 - 3366 - 613 - 2015 26420826
    13 - 3581 - 608 - 2015 26420826
    13 - 2944 - 568 - 2015 26420826
    12 - 2873 - 433 - 2015 26420826
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   highly
     salivary gland   highly
    Endocrineadrenal gland   highly
    Lymphoid/Immunelymph node   highly
     spleen   highly
     tonsils   highly
    Nervousnervecranial nerve  highly
    Reproductivefemale systemuteruscervix highly
     male systemtestis  highly
    Skin/Tegumentskin   highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  moderately
    Epithelialsecretoryglandularendocrine 
    cell lineage hemapoietic cells
    cell lines
    fluid/secretion highly in blood and lymph
    at STAGE
    physiological period fetal, pregnancy
    Text liver, placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a nuclear localization signal
  • a K homology (KH) motif bound to a RNA binding motif
  • a CCHC-type zinc finger domain
  • a conserved SPSP motif in a coiled-coil domain of SF1 is highly phosphorylated in proliferating human cells and is required for cell proliferation
  • a C terminal glutamine and proline rich domain
  • conjugated PhosphoP , Other
    mono polymer complex
    HOMOLOGY
    interspecies homolog to rattus Zfp162 (96.8 pc)
    homolog to murine Sf1 (99.2 pc)
    Homologene
    FAMILY
  • zinc finger protein family
  • BBP/SF1 family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • distributed throughout the nucleoplasm, where transcription occurs, with additional concentration in nuclear speckles, where splicing factors accumulate when not engaged in splicing
  • basic FUNCTION
  • being necessary for the ATP-dependent first step of spliceosome assembly
  • potentially involved in regulating RNA cellular metabolism
  • may act as transcription repressor
  • SF1 and U2AF2 associate cooperatively with pre-mRNA and play a crucial role in 3 prime splice site recognition during early steps of spliceosome assembly
  • RNA polymerase II transcription factor activity
  • role for SF1 and branch site-like sequences in splice site selection
  • SF1 and U2 auxiliary factor (U2AF2) cooperatively recognize the 3 prime splice site during the initial stages of pre-mRNA splicing
  • represses proinflammatory gene expression in vascular smooth muscle cells (SMCs) at a global level and thus may also be involved in the attenuation of growth factor-induced phenotype changes in these cells
  • the essential splicing factors U2AF2 and SF1 cooperatively bind consensus sequences at the 3' end of introns
  • CELLULAR PROCESS nucleotide, transcription, maturation
    nucleotide, transcription, regulation
    nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • acetylated
  • spliceosome complex
  • SF1 and U2AF form extraspliceosomal complexes before and after taking part in the assembly of catalytic spliceosomes
  • INTERACTION
    DNA binding
    RNA
  • interacting with U1 snRNA
  • binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA
  • small molecule metal binding,
  • Zn2+
  • protein
  • binding to the RRM3 motif of U2AF65
  • binding to EWSR1
  • binding to FUS
  • binding to TAF15
  • binding to U2AF2
  • direct binding of SF1 to U2AF2 in both the nucleoplasm
  • and nuclear speckles
  • TRAPPC2 interaction with the transcription factors ENO1, PITX1 and SF1
  • antagonizes PDGFB-induced growth and dedifferentiation of vascular smooth muscle cells
  • PRPF40B interacts directly with SF1 and associates with U2AF2
  • U2AF2 interacts with SF1 and was shown to recruit the U2 snRNP to the spliceosome
  • interacts with SURP domains of U2 snRNP-associated proteins
  • cell & other
    REGULATION
    induced by CSF2 (forms ABCDF and B4)
    inhibited by phosphorylation of ser20, interfering with U2AF65 binding and spliceosome assembly
    Phosphorylated by UHMK1, that double-phosphorylates both serines of the SPSP motif
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS