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FLASH GENE
Symbol SETD7 contributors: shn/npt - updated : 29-04-2009
HGNC name SET domain containing (lysine methyltransferase) 7
HGNC id 30412
Location 4q31.1      Physical location : 140.427.192 - 140.477.577
Synonym name
  • SET domain-containing protein 7
  • histone H3-lysine 4-specific methyltransferase
  • SET domain-containing protein 7
  • Synonym symbol(s) KMT7, SET9, SET7/9, FLJ21193, KIAA1717, SET7, H3-K4-HMTase
    EC.number 2.1.1.43
    DNA
    TYPE functioning gene
    STRUCTURE 50.39 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    mode radiation hybrid
    Map SETD7 has been mapped on chromosome 4q by radiation hybridation
    regionally located cen - D4S1576 - D4S2972 - SETD7 - D4S1579 - D4S397 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 7012 45 366 - Wang (2001)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     thymus   highly
    Reproductivefemale systemuterus  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three MORN repeats
  • one SET domain in C terminus, implicated in protein lysine methylation
  • one N-terminal beta-sheet domain
  • HOMOLOGY
    interspecies ortholog to setd7, Danio rerio
    ortholog to Setd7, Mus musculus
    ortholog to Setd7, Rattus norvegicus
    ortholog to SETD7, Pan troglodytes
    Homologene
    FAMILY
  • histone-lysine methyltransferase family
  • SET7 subfamily
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • methylating Lys-4 of histone H3, a specific tag for epigenetic transcriptional activation
  • controlling the opening or closing of chromatin
  • required for heterochromatin formation
  • potentiating transcription activation
  • plays a central role in the transcriptional activation of genes such as collagenase or insulin
  • Set9 specifically methylates p53 at lys372 within the C-terminal regulatory region
  • Set9 may be regulate function of non-histone proteins which plays a role of transcription activation
  • Set9 functions as a transcriptional regulator through lysine methylation for p53, TAF10 and Estrogen receptor alpha
  • Set9 methylates p300/CBP-associated factor (PCAF) at multiple lysine residues
  • catalyze the site-specific methylation of protein lysyl residues in a host of proteins, including histones, transcription factors, chromatin-modifying enzymes, ribosomal subunits, and other substrates
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    PHYSIOLOGICAL PROCESS
    text histone lysine methyltransferase activity
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • AdoMet (S-adenosyl-l-methionine)
  • p300/CBP-associated factor (PCAF) a substrate of Set9 methyltransferase
  • protein
  • IPF1/PDX-1
  • p300/CBP-associated factor (PCAF)
  • regulates DNA methyltransferase-1 (DNMT1) activity in mammalian cells by promoting degradation of DNMT1 and thus allows epigenetic changes via DNA demethylation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS