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FLASH GENE
Symbol SETD6 contributors: mct - updated : 17-06-2014
HGNC name SET domain containing 6
HGNC id 26116
Location 16q21      Physical location : 58.549.382 - 58.554.430
Synonym name
  • N-lysine methyltransferase SETD6
  • DNA
    TYPE functioning gene
    STRUCTURE 5.75 kb
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2985 - 473 - -
    8 - 2913 - 449 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • is a transcriptional repressor, in agreement with its association with HDAC1 and MTA2
  • is an essential factor for nuclear receptor signaling and cellular proliferation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • lysine methylation of the NFKB1 subunit RELA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NFKB1 signaling
  • monomethylates the RELA subunit of nuclear factor kappa B (NFKB1)
  • H2AFZ is monomethylated at lysine 7 (H2AZK7me1) by the lysine methyltransferase SETD6
  • association with HDAC1 and MTA2
  • modifies the histone variant H2AZ, a key component of nuclear receptor-dependent transcription
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS