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FLASH GENE
Symbol SETD3 contributors: mct - updated : 31-10-2012
HGNC name SET domain containing 3
HGNC id 20493
Location 14q32.2      Physical location : 99.864.083 - 99.947.226
Synonym name
  • histone-lysine N-methyltransferase setd
  • Synonym symbol(s) C14orf154
    EC.number 2.1.1.43
    DNA
    TYPE functioning gene
    STRUCTURE 83.14 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2905 - 594 - 2011 21832073
    9 - 1441 - 296 - 2011 21832073
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatum  highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Muscularmyocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a SET (Su(var)39 domain found in histone methyltransferases and other lysine methyltransferases
  • Enhancer-of-zeste and Trithorax
  • Rubis-subs-bind domains
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • novel histone H3K4 and H3K36 methyltransferase with transcriptional activation activity
  • plays an important role in the transcriptional regulation of muscle cell differentiation, by regulating muscle-specific factors, most notably myogenin, through interaction with MYOD1
  • involved in a translocation to the immunoglobulin lambda light chain locus in one of the non-homologous end-joining/p53-deficient peripheral B cell lymphomas
  • exhibits histone methyltransferases activity on nucleosomal histone 3 in a SET-domain dependent manner
  • may play an important role in carcinogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with MYOD1 and is recruited to myogenin gene promoter
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS