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FLASH GENE
Symbol SESN3 contributors: mct/npt - updated : 03-03-2010
HGNC name sestrin 3
HGNC id 23060
Location 11q21      Physical location : 94.906.132 - 94.964.246
Synonym symbol(s) SEST3, MGC29667
DNA
TYPE functioning gene
STRUCTURE 58.11 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 1987 - 492 - Peeters (2003)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • sestrin family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in cell cycle arrest
  • exhibit oxidoreductase activity and may function as antioxidants (Lee 2010)
  • important negative feedback regulator of MTOR whose loss results in various MTOR-dependent, age-related pathologie (Lee 2010)
  • important homeostatic function for the stress-inducible Sestrin protein family SESN2 and SESN3 in the control of mammalian lipid and glucose metabolism
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS