basic FUNCTION
| may be involved in cellular response to different stress conditions (Budanov 2002) |
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may function in the regulation of cell growth and survival |
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involved in the induction of autophagy in TP53-proficient cells (Maiuri 2009) |
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exhibit oxidoreductase activity and may function as antioxidants (Lee 2010) |
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important negative feedback regulator of MTOR whose loss results in various MTOR-dependent, age-related pathologie (Lee 2010) |
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important homeostatic function for the stress-inducible Sestrin protein family SESN2 and SESN3 in the control of mammalian lipid and glucose metabolism |
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is a new energetic stress sensor, which appears to be protective against energetic stress-induced apoptosis that integrates the pro-survival function of AKT1 and the negative regulation of MTOR |
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antioxidant function of SESN2 limits neuropathic pain processing |
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SESN2 and AMP-activated protein kinase (AMPK), important for the maintenance of metabolic homeostasis, are also stress-inducible proteins that are critical for the suppression of ROS production and protection from oxidative stress |
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SESN2 and antioxidants inhibit UCP1 expression through suppressing ROS-mediated MAPK14 activation, implying a critical role of ROS in proper BAT metabolism |
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autophagy-controlling function of SESN2 may be important for its other physiological functions |
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is a promoter of ULK1-mediated SQSTM1 phosphorylation |
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conserved antioxidant protein that accumulate in cells in response to various stresses |
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inhibits TLR-induced proinflammatory signaling and protects cells by inhibiting JNK- or MAPK14-mediated JUN phosphorylation |
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is likely a crucial modulator for the production of reactive oxygen species (ROS) |
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transient global ischemia (TGI)-induced SESN2 expression contributed to RPS6 phosphorylation and neuroprotection against ischemic injury in the hippocampal CA1 subfield |