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FLASH GENE
Symbol SESN1 contributors: mct/npt - updated : 26/09/2008
HGNC name sestrin 1
HGNC id 21595
Location 6q21      Physical location : 109.307.646 - 109.415.277
Synonym name
  • TP53 regulated nuclear protein
  • p53 regulated PA26 nuclear protein
  • Synonym symbol(s) PA26, SEST1, MGC138241, MGC142129, RP11-787I22.1
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 107.63 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    regionally located region associated with deletions in a number of cancers
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 splicing 2785 68 551 - Velasco-Miguel, Peeters (2003)
  • also called PA26-T1
  • not induced by p53
  • - splicing 2685 56.6 492 - Velasco-Miguel (1999)
  • also called PA26-T2
  • induced by genotoxic stress (UV,gamma-irradiation and cytotoxic drugs) in a p53-dependent manner
  • - splicing 2734 48 426 - Velasco-Miguel (1999)
  • also called PA26-T3
  • induced by genotoxic stress (UV,gamma-irradiation and cytotoxic drugs) in a p53-dependent manner
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrineneuroendocrinepituitary  highly
    Nervousbrain    
    Reproductivemale systemtestis  highly
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Lymphoid    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text ectodem, notochord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Pa26-pending
    homolog to Drosophila CG11299
    ortholog to xenopus Xpa26
    Homologene
    FAMILY
  • GADD family (growth arrest and DNA damage-inducible stress-response gene)
  • sestrin family
  • CATEGORY regulatory , signaling growth factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • having a role in the regulation of cell growth
  • required for normal embryonic left-right determination, playing a role in mediating Nodal signaling, and being indispensable gene for vertebrate left-right asymmetry
  • exhibit oxidoreductase activity and may function as antioxidants (Lee 2010)
  • important negative feedback regulator of MTOR whose loss results in various MTOR-dependent, age-related pathologie (Lee 2010)
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text negative regulation of cell proliferation ; response to DNA damage
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TP53 target gene
  • physically interacts with FOXH1 or a FOXH1-containing complex
  • SESN1 and SESN2 interact with the NFE2L2 suppressor KEAP1, the autophagy substrate SQSTM1, and the ubiquitin ligase RBX1 and the antioxidant function of SESNs is mediated through activation of NFE2L2 in a manner reliant on SQSTM1-dependent autophagic degradation of KEAP1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in a number of cancers and in heterotaxia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS