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FLASH GENE
Symbol SERTAD3 contributors: mct/npt - updated : 26-08-2019
HGNC name SERTA domain containing 3
HGNC id 17931
Location 19q13.2      Physical location : 40.946.748 - 40.950.282
Synonym name
  • RPA-binding trans-activator
  • replication protein binding transactivator 1
  • Synonym symbol(s) RBT1
    DNA
    TYPE functioning gene
    STRUCTURE 3.54 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - D19S425 - D19S208 - D19S224 - D19S228 - D19S421 - CLC - FBL , SERTAD3 , SNRPA , D19S223 - D19S217 - D19S211 - qter
    Authors Gene Map
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1527 - 196 - 2007 1726002
    2 - 1416 - 196 - 2007 1726002
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Nervousnerve   highly
    Reproductivefemale systemovary  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text whole
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal basic cyclin A-binding motif
  • a PHD-bromo binding domain,
  • a novel motif termed SERTA (SERTAD1, SERTAD3 and TARA)
  • and a conserved C-terminus
  • HOMOLOGY
    Homologene
    FAMILY SERTA domain family of proteins
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • transcriptional activator of RPA complex, contributing to oncogenesis, at least in part, via an E2F-dependent mechanism
  • SERTAD2, SERTAD3 function by interacting with a wide variety of bromodomain-containing transcriptional regulators in different subcellular locales
  • primarily activates the autophagy and suppresses apoptosis in nutrient sufficient condition
  • is a tumor suppressor rather than onco-protein
  • CELLULAR PROCESS nucleotide, replication
    nucleotide, recombination
    nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MDFI specifically interacts with other SERTA domain-containing proteins, including SERTAD3 and SERTAD4, through its I-mfa domain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS