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FLASH GENE
Symbol SERTAD2 contributors: - updated : 23-08-2007
HGNC name SERTA domain containing 2
HGNC id 30784
Location 2p14      Physical location : 64.858.755 - 64.881.046
Synonym name transcriptional regulator interacting with the PHD-bromodomain 2
Synonym symbol(s) TRIP-Br2, KIAA0127, MGC126688, MGC126, Sei-2
DNA
TYPE functioning gene
STRUCTURE 22.00 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a SERTA domain
  • a conserved PHD-Bromo binding domain, an interaction module for bromodomain-containing proteins
  • HOMOLOGY
    interspecies ortholog to murine Sertad2
    Homologene
    FAMILY TRIP-Br family
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • acting at E2F-responsive promoters to integrate signals provided by PHD- and/or bromodomain-containing transcription factors
  • activate transcription when recruited to a target promoter
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS