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FLASH GENE
Symbol SERTAD1 contributors: - updated : 23-08-2007
HGNC name SERTA domain containing 1
HGNC id 17932
Location 19q13.1-q13.2      Physical location : 40.928.410 - 40.931.932
Genatlas name CDK4 binding protein p34
Synonym name
  • CDK4-binding protein p34SEI
  • transcriptional regulator interacting with the PHD-bromodomain 1
  • Synonym symbol(s) SEI1, TRIP-Br1
    DNA
    TYPE functioning gene
    STRUCTURE 3.00 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Lymphoid/Immunetonsils   highly
    Reproductivefemale systemovary  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved PHD-Bromo binding domain
  • an interaction module for bromodomain-containing proteins
  • HOMOLOGY
    Homologene
    FAMILY TRIP-BR family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • antagonizing the function of CDKN2A
  • involved in cell cycle regulations by interacting with a number of important proteins including CDK4
  • activate transcription when recruited to a target promoter
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CDK4 (regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner)
  • interacting with CREBBP (association with CREBBP is not only involved in cell cycle regulation by CREBBP, but also have some effect on other CREBBP-dependent transcription)
  • also interacts with CDKN3, a bromodomain-containing corepressor suggesting that not all bromodomains are associated with transcriptional activation only
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS