| basic FUNCTION
| effective inhibitor of angiogenesis especially in controlling the growth of blood vessels in the eye and in bone (matrix remodeling) |
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preventing against early diabetic retinopathy |
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estrogen sensitive and inhibiting the growth of ovarian tissue |
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neuroprotective and anti-angiogenic factor, may play an important role in the pathogenesis of diabetic retinopathy |
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important neuromodulatory factor that can provide effective neuroprotection and a primary endogenous angiogenic inhibitor in the eye |
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may play a role in the pathogenesis of neurodegenerative diseases and angiogenic disorders, such as Alzheimer's disease, Parkinson disease, neovascular age-related macular degeneration and tumors |
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suspected tumor suppressor gene that plays a key role in the inhibition of epithelial tissue growth  |
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inducing apoptosis in endothelial cells by activating MAPK14 dependent cleavage of multiple caspases |
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may play an important role in the pathogenesis of diabetic retinopathy, in cooperation with the VEGF gene |
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possibly involved in bone homeostasis as an inhibitor of bone resorption |
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inhibits osteoclast function via regulating osteoprotegerin expression, and thereby contributes to the maintenance of bone homeostasis |
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neurotrophic factor at first, but it also possesses neuro-protective, pro-differentiation, anti-proliferative and anti-angiogenic functions (most potent endogenous inhibitor of angiogenesis) |
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inhibits osteoclast differentiation and hence bone resorption via osteoprotegerin (OPG) and TNFSF11 (receptor activator of NF-kB ligand) in a dose-dependent manner |
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multifunctional protein and one of the strongest inhibitors of angiogenesis |
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stimulates macrophage-mediated cytotoxicity in a TNFSF10-dependent manner |
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able to enhance the antitumor efficacy of macrophages by inducing a TNFSF10-mediated tumoricidal activity |
