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FLASH GENE
Symbol SERPINB9 contributors: mct - updated : 08-03-2008
HGNC name serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9
HGNC id 8955
Location 6p25      Physical location : 2.887.505 - 2.903.545
Synonym name
  • protease inhibitor 9 (ovalbumin type), granzyme B inhibitor
  • Synonym symbol(s) PI9, CAP3, CAP-3
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text clustered with PI9, ELANH2
    STRUCTURE 16.00 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 4121 - 376 - Kummer (2007)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessels    
    Digestivesalivary gland   highly
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systemovary   
     female systemplacenta  highly
     male systemtestis   
    Respiratorylung    
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialbarrier/lining   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to highly,to the genes of the serpin cluster on chromosome 18 (SPI@2)
    Homologene
    FAMILY serpin family, ovalbumin subgroup
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • can regulate pro-apoptotic apical caspases
  • potent inhibitor of GZMB, and protects testicular Sertoli cells and placental syncytial trophoblasts from GZMB-producing auto- or allo-reactive cytotoxic lymphocytes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • inhibited apoptotic death by directly interacting with the intermediate active forms of caspase-8 and -10
  • potent inhibitor of the cytotoxic lymphocyte (CL) proteinase granzyme B, a major effector molecule used by CLs to induce target cell apoptosis
  • cell & other
    REGULATION
    inhibited by GZMM
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in gestational trophoblastic diseases contributes to disease pathogenesis via immune evasion
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS