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FLASH GENE
Symbol SERPINB1 contributors: mct - updated : 23-11-2017
HGNC name serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1
HGNC id 3311
Location 6p25.2      Physical location : 2.833.735 - 2.842.081
Synonym name
  • protease inhibitor 2 (anti-elastase), monocyte/neutrophil derived
  • Leukocyte Elastase Inhibitor
  • Synonym symbol(s) EI, LEI, PI2, MNEI, ELANH2, ILEU, HEL-S-27, HEL57, M/NEI, MNEI, PI-2
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text
  • clustered with PI9, highly homologous to the genes of the serpin cluster on chromosome 18 (SPI@2)
  • STRUCTURE 9.72 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - SERPINB6 - D6S1338 - SERPINB9 - SERPINB1 - F13A1 F13A1 - D6S89 - D6S105 - cen
    Authors Evans (95),Sun (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2678 - 379 - 2016 27107834
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     intestinesmall intestine   
     salivary gland    
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Epithelialbarrier/lining   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY serpin family, ov-serpin subfamily
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic,granule
    basic FUNCTION
  • regulating acitivity of the neutrophil proteases, elastase, cathepsin G and proteinase 3
  • inhibitory role of SERPINB1 in the migration and invasion of Hepatocellular carcinoma
  • negatively regulates glioma cell migration and invasion probably by abrogating the expression of MMP2 and the activation of PTK2
  • is an endogenous protein that can potentially be harnessed to enhance functional beta cell mass in patients with diabetes
  • intracellular protein and acts primarily to protect the cell from proteases released into the cytoplasm during stress
  • has also a role in cell migration suggesting that it could be involved in diverse processes like wound healing and malignant metastases
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cytotoxic function for the serine protease CTSG and SERPINB1 is critical for maintaining polymorphonuclear neutrophils (PMNs) survival by antagonizing intracellular CTSG activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in patients with type 2 diabetes compared with that in healthy subjects and are negatively correlated with serum LDL-C
    tumoral     --low  
    in high-grade human glioma tissue samples and glioblastoma cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker might be a potential prognostic indicator of hepatocellular carcinoma metastasis
    Therapy target
    ANIMAL & CELL MODELS