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FLASH GENE

Symbol

SERPINA6

contributors: - updated : 09-12-2005

HGNC name	serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
HGNC id	1540

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	CBG corticosteroid binding globulin deficiency
Location	14q32.1      Physical location : 94.770.585 - 94.789.688
Synonym name	corticosteroid binding globulin
	transcortin
Synonym symbol(s)	CBG

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	19.00 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

text structure

( 5'intronic promoter) binded to several nuclear matrix attachment region (MAR)

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Respiratory lung

cell lineage
cell lines	hepatoma cells
fluid/secretion	plasma

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

member of the serpin superfamily

CATEGORY

enzyme , transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth

basic FUNCTION	corticosteroid binding globulin
	serine proteinase inhibitor
	involved in the regulation of gene activity and chromatin structure

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CBG

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS