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FLASH GENE
Symbol SERPINA6 contributors: - updated : 09-12-2005
HGNC name serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
HGNC id 1540
Corresponding disease
CBG corticosteroid binding globulin deficiency
Location 14q32.1      Physical location : 94.770.585 - 94.789.688
Synonym name
  • corticosteroid binding globulin
  • transcortin
  • Synonym symbol(s) CBG
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 19.00 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure ( 5'intronic promoter) binded to several nuclear matrix attachment region (MAR)
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC388006 14 LOC388006 C14orf86 14 chromosome 14 open reading frame 86 LOC90050 14q32.13 hypothetical protein BC009073 ASB2 14q31-q32 ankyrin repeat and SOCS box-containing 2 C14orf48 14q32.13 chromosome 14 open reading frame 48 C14orf137 14q32.13-q32.2 chromosome 14 open reading frame 137 DDX24 14q32 DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 FAM14B 14q32.13 family with sequence similarity 14, member B IFI27 14q32 interferon, alpha-inducible protein 27 FAM14A 14q32.13 family with sequence similarity 14, member A KIAA1622 14q32.2 KIAA1622 SERPINA10 14q32.13 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 SERPINA6 14q32.1 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 LOC390502 14 similar to Alpha-1-antitrypsin-related protein precursor SERPINA1 14q32.1 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 LOC256394 14q32.2 similar to serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4; protease inhibitor 4 (kallistatin) SERPINA11 14q32.2 similar to serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4; protease inhibitor 4 (kallistatin) OL-64 14q32.2 visceral adipose-specific SERPIN SERPINA4 14q32.1 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 SERPINA5 14q32.11 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 SERPINA3 14q32.11 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 LOC390503 14 similar to adiponectin receptor 1; CGI-45 protein LOC388007 14 similar to protease inhibitor
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Respiratorylung    
    cell lineage
    cell lines hepatoma cells
    fluid/secretion plasma
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY member of the serpin superfamily
    CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • corticosteroid binding globulin
  • serine proteinase inhibitor
  • involved in the regulation of gene activity and chromatin structure
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CBG
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS