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FLASH GENE
Symbol SERPINA5 contributors: - updated : 15-12-2005
HGNC name serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
HGNC id 8723
Location 14q32.11      Physical location : 95.047.730 - 95.059.457
Synonym name protein C inhibitor (plasminogen activator inhibitor-3)
Synonym symbol(s) PCI, PAI3, PROCI, PLANH3
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 11.00 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
IFI27 14q32 interferon, alpha-inducible protein 27 FAM14A 14q32.13 family with sequence similarity 14, member A KIAA1622 14q32.2 KIAA1622 SERPINA10 14q32.13 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 SERPINA6 14q32.1 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 LOC390502 14 similar to Alpha-1-antitrypsin-related protein precursor SERPINA1 14q32.1 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 LOC256394 14q32.2 similar to serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4; protease inhibitor 4 (kallistatin) SERPINA11 14q32.2 similar to serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4; protease inhibitor 4 (kallistatin) OL-64 14q32.2 visceral adipose-specific SERPIN SERPINA4 14q32.1 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 SERPINA5 14q32.11 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 SERPINA3 14q32.11 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 LOC390503 14 similar to adiponectin receptor 1; CGI-45 protein LOC388007 14 similar to protease inhibitor LAMR1P4 14 laminin receptor 1 pseudogene 4 GSC 14q32.1 goosecoid RPL15P2 14 ribosomal protein L15 pseudogene 2ribosomal protein L15 pseudogene 2 LOC256453 14q32.2 hypothetical LOC256453
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Lymphoid/Immunespleen   highly
Reproductivemale systemtestis  highly
cell lineage
cell lines
fluid/secretion plasma
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies homolog to murine Serpina5
Homologene
FAMILY serpin family
CATEGORY enzyme , regulatory
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
basic FUNCTION
  • inhibiting activated protein C as well as plasminogen activators
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS