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FLASH GENE
Symbol SERPINA12 contributors: sge/npt/pgu - updated : 24-02-2015
HGNC name serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
HGNC id 18359
Location 14q32.13      Physical location : 94.953.620 - 94.984.181
Synonym name
  • vaspin
  • visceral adipose-specific SERPIN
  • visceral adipose tissue-derived serine protease inhibitor
  • serpin A12
  • serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
  • Synonym symbol(s) OL-64, Vaspin
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text serine protease inhibitor (serpin) gene cluster
    STRUCTURE 30.56 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2087 - 414 - 2004 15014966
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue   
    Reproductivefemale systemplacenta    Homo sapiens
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificadipocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • serine protease inhibitor (serpin) family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • adipokine with insulin-sensitizing effects, which is predominantly secreted from visceral adipose tissue in diabetes
  • exerting an insulin-sensitizing effect targeted toward visceral white adipose tissues in states of obesity
  • IAPP and SERPINA12 are modulated by energy status in the placenta, which suggests that these proteins may be involved in the regulation of placental metabolic functions (pMID: 19554505)
  • acting as regulator of insulin sensitivity but also as mediators of the inflammatory process
  • adipocytokine with insulin-sensitizing effects
  • protects vascular endothelial cells from free fatty acid-induced apoptosis through upregulation of the PI3-kinase/Akt signaling pathway
  • activates the PI3-kinase/Akt signaling cascade in aortic endothelial cells
  • is a novel adipocytokine with anti-inflammatory property in vascular SMCs
  • is a novel ligand for cell-surface HSPA5/DNAJC1 complex, and its subsequent signals exert beneficial effects on ER stress-induced metabolic dysfunctions
  • protects osteoblasts (hOBs) from serum deprivation-induced apoptosis, which may be mediated by activating the MAPK/ERK signaling pathway
  • might attenuate the cytokine-induced expression of adhesion molecule genes by inhibiting NFKB1 following AMPK activation
  • role of vaspin in atherosclerosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SERPINA12 significantly inhibited PDGFB-induced smooth muscle cells (SMCs) migration
  • PDGFB-induced activation of MAPK14 was significantly suppressed by SERPINA12
  • binds to cell-surface HSPA5, which is recruited from ER to plasma membrane under ER stress
  • likely downregulates osteoclastogenesis in part by inhibiting expression of the transcription factor NFATC1
  • KLK7 inhibition by SERPINA12 is an underlying physiological mechanism for its compensatory actions on obesity-induced insulin resistance
  • cell & other
    REGULATION
    Other expression in adipose tissue is regulated in a fat depot-specific manner and could be associated with parameters of obesity, insulin resistance, and glucose metabolism
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    only expressed in patients with type 2 diabetes
    constitutional     --over  
    associated with obesity and impaired insulin sensitivity
    constitutional     --over  
    serum vaspin concentrations were significantly higher in patients with ulcerative colitis (UC) than in patients with Crohn disease (CD) and controls
    constitutional     --over  
    Vaspin levels have been shown to increase in acute ischemic stroke patients
    constitutional     --over  
    SERPINA12 and ITLN1 are up-regulated in large for gestational age infants at term
    Susceptibility
  • to carotid atherosclerosis
  • to Chronic Obstructive Pulmonary Disease
  • Variant & Polymorphism SNP
  • SNP rs2236242 associated with type 2 diabete mellitus with the AA genotype bearing an increased risk
  • serum vaspin level was positively associated with carotid intima-media thickness (c-IMT) and carotid atherosclerosis
  • SNP (rs140198372), in SERPINA12, increase the risk of Chronic Obstructive Pulmonary Disease (COPD)
  • Candidate gene
  • serum SERPINA12 is one of the predictors for insulin-resistance in obese children
  • serum concentration is altered in patients with non-alcoholic fatty liver disease
  • Marker
  • may aid the auxiliary diagnosis of UC and may be useful for assessing disease activity in patients
  • Therapy target
    SystemTypeDisorderPubmed
    obesity  
    promising candidate for drug development for the treatment of obesity-related insulin resistance and inflammation
    diabetetype 2 
    promising candidate for drug development for the treatment of obesity-related insulin resistance and inflammation
    ANIMAL & CELL MODELS
  • vaspin-deficient mice developed glucose intolerance associated with upregulation of ER stress markers