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FLASH GENE
Symbol SERP1 contributors: mct - updated : 07-04-2014
HGNC name stress-associated endoplasmic reticulum protein 1
HGNC id 10759
Location 3q25.1      Physical location : 150.259.780 - 150.264.428
Synonym name
  • ribosome associated membrane protein 4
  • Synonym symbol(s) RAMP4, MGC117327, MGC133321, MGC133322
    DNA
    TYPE functioning gene
    STRUCTURE 4.65 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    MAPPING cloned Y linked N status provisional
    Physical map
    RPL38P1 3q21-q25 ribosomal protein L38 pseudogene 1 AGTR1 3q21-q25 angiotensin II receptor, type 1 CPB1 7p14-p13 carboxypeptidase B1 (tissue) CPA3 3q21-q25 carboxypeptidase A3 (mast cell) LOC285329 3q24 similar to Ataxin-1 ubiquitin-like interacting protein GYG 3q24 glycogenin SMARCA3 3q25.1-q26.1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3 HPS3 3q24-q25.1 Hermansky-Pudlak syndrome 3 CP 3q23-q25 ceruloplasmin (ferroxidase) LOC389160 3 LOC389160 LOC116441 3q24 hypothetical protein BC014339 TM4SF1 3q21-q25 transmembrane 4 superfamily member 1 TM4SF4 3q25 transmembrane 4 superfamily member 4 TAZ Xq28 tafazzin (cardiomyopathy, dilated 3A (X-linked); endocardial fibroelastosis 2; Barth syndrome) LOC51122 3q25.1 HSPC042 protein LOC389161 3 hypothetical gene supported by AK027233 LOC389162 3 LOC389162 LOC389163 3 hypothetical gene supported by AK098078 RNF13 3q25.1 ring finger protein 13 PFN2 3q25.1-q25.2 profilin 2 LOC389164 3 similar to Chromosome 1 open reading frame 37 LOC391587 3 similar to peptidyl-Pro cis trans isomerase LOC389165 3 hypothetical gene supported by AF090923; AK023388; BC002719 LOC389166 3 LOC389166 KIAA0669 3q25.1-q25.2 LOC389166 SERP1 3q25.1 stress-associated endoplasmic reticulum protein 1 eIF2A 3q25.1 eukaryotic translation initiation factor (eIF) 2A SELT 3q25.1 selenoprotein T MGC39662 3q25.1 hypothetical protein MGC39662 LOC391588 3 similar to U1 small nuclear ribonucleoprotein C (U1-C) SIAH2 3q25 seven in absentia homolog 2 (Drosophila) LOC389167 3 LOC389167 USH3A 3q21-q25 Usher syndrome 3A TRALPUSH 3q25.1 TRALPUSH H963 3q25.1 TRALPUSH GPR105 3q21-q25 G protein-coupled receptor 105 GPR87 3q24 G protein-coupled receptor 87 GPR86 3q24 G protein-coupled receptor 86 P2RY12 3q24-q25 purinergic receptor P2Y, G-protein coupled, 12 FLJ25972 3q25.1 hypothetical protein FLJ25972 LOC344752 3q25.1 similar to Arylacetamide deacetylase LOC201651 3q25.1 similar to esterase/N-deacetylase (EC 3.5.1.-), 50K hepatic - rabbit AADAC 3q21.3-q25.2 arylacetamide deacetylase (esterase) GPR91 3q24-3q25.1 G protein-coupled receptor 91 MBNL1 3q25.1-q25.2 muscleblind-like (Drosophila)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3181 - 66 - 2006 16705175
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-terminal transmembrane region that mediates post-translational insertion into the membrane of the endoplasmic reticulum (ER)
  • HOMOLOGY
    interspecies homolog to murine D3Ucla1
    homolog to rattus RAMP4
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,cytoplasm,cytoskeleton,microtubule
    text newly synthesised SERP1 and SEC61B can accumulate in a cytosolic, soluble complex with the ATPase ASNA1 before insertion into ER-derived membranes
    basic FUNCTION
  • stabilizes membrane proteins during stress and facilitates subsequent glycosylation
  • tail-anchored (TA) protein, having a functions in the ER stress response
  • represents an oxidative stress-associated endoplasmatic reticulum protein with chaperon-like functions
  • both VKORC1 and SERP1, might have a synergistic function in eliminating reactive oxygen species generated during the VKOR redox process
  • expression of SERP1 strongly inhibits amiloride-sensitive Na(+) transport
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CANX
  • VKORC1 interacting with SERP1, and both might have a synergistic function in eliminating reactive oxygen species generated during the VKOR redox process
  • induced during cell stress and interacts with the molecular chaperone calnexin, thus controlling early biogenesis of membrane proteins
  • appears to promote expression of CFTR and is a novel cochaperone and regulator of SCNN1A, SCNN1B, SCNN1G expression
  • cell & other
    REGULATION
    induced by ER stress (SEC61-associated polypeptide that is induced by ER stress)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    leading to ER stress
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Serp1-/- mice, made by targeted gene disruption, demonstrated growth retardation, increased mortality, and impaired glucose tolerance