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FLASH GENE

Symbol

SERP1

contributors: mct - updated : 07-04-2014

HGNC name	stress-associated endoplasmic reticulum protein 1
HGNC id	10759

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3q25.1      Physical location : 150.259.780 - 150.264.428
Synonym name	ribosome associated membrane protein 4
Synonym symbol(s)	RAMP4, MGC117327, MGC133321, MGC133322

DNA

TYPE	functioning gene
STRUCTURE	4.65 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014445 3 - 3181 NP_055260 - 66 - 2006 16705175

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas       highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

C-terminal transmembrane region that mediates post-translational insertion into the membrane of the endoplasmic reticulum (ER)

HOMOLOGY

interspecies	homolog to murine D3Ucla1
	homolog to rattus RAMP4

Homologene

FAMILY

CATEGORY

chaperone/stress

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,cytosolic,ribosome
	intracellular,cytoplasm,cytoskeleton,microtubule
text	newly synthesised SERP1 and SEC61B can accumulate in a cytosolic, soluble complex with the ATPase ASNA1 before insertion into ER-derived membranes

basic FUNCTION	stabilizes membrane proteins during stress and facilitates subsequent glycosylation
	tail-anchored (TA) protein, having a functions in the ER stress response
	represents an oxidative stress-associated endoplasmatic reticulum protein with chaperon-like functions
	both VKORC1 and SERP1, might have a synergistic function in eliminating reactive oxygen species generated during the VKOR redox process
	expression of SERP1 strongly inhibits amiloride-sensitive Na(+) transport

CELLULAR PROCESS

protein, post translation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with CANX
	VKORC1 interacting with SERP1, and both might have a synergistic function in eliminating reactive oxygen species generated during the VKOR redox process
	induced during cell stress and interacts with the molecular chaperone calnexin, thus controlling early biogenesis of membrane proteins
	appears to promote expression of CFTR and is a novel cochaperone and regulator of SCNN1A, SCNN1B, SCNN1G expression

cell & other

REGULATION

induced by

ER stress (SEC61-associated polypeptide that is induced by ER stress)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     leading to ER stress

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Serp1-/- mice, made by targeted gene disruption, demonstrated growth retardation, increased mortality, and impaired glucose tolerance