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FLASH GENE
Symbol SERBP1 contributors: mct - updated : 07-03-2018
HGNC name SERPINE1 mRNA binding protein 1
HGNC id 17860
Location 1p31.3      Physical location : 67.873.494 - 67.896.123
Synonym name
  • PAI-1 mRNA-binding protein
  • chromodomain helicase DNA binding protein 3 interacting protein
  • Plasminogen activator inhibitor 1 RNA binding protein
  • Synonym symbol(s) CGI-55, FLJ90489, PAI-RBP1, CHD3IP, HABP4L, RDA288, PAIRBP1
    DNA
    TYPE functioning gene
    STRUCTURE 22.63 kb     8 Exon(s)
    regulatory sequence Promoter
    Binding site
    text structure
  • binding of NR5A2 to the promoter region of SERBP1 resulted in a decrease in the expression level of the reporter gene, subsequently inhibiting transcription
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 6764 44 408 - 2017 28267599
    8 - 6746 - 402 - 2017 28267599
    8 - 6719 - 393 - 2017 28267599
    8 - 6701 - 387 - 2017 28267599
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     mouthtongue   
    Reproductivefemale systemuterus   
     male systemtestis   
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an RGG box
  • an RG-rich region
  • an arg-rich region
  • a putative protein kinase A phosphorylation site
  • several putative hyaluronic acid binding sites
  • C-terminal third of the SERBP1 protein, which contains one of its two substrate sites for PRMT1, is necessary and sufficient for it to interact with RACK1
  • HOMOLOGY
    interspecies homolog to rattus Rda288
    intraspecies paralog to HABP4
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleolus
    text
  • localizes to the nucleolus and co-localizes with p80-coilin positive nuclear-coiled bodies
  • PGRMC1 and SERBP1 colocalized in the cytoplasmic fractions of nondecidualized and decidualized endometrial stromal cells (ESCs)
  • basic FUNCTION
  • may have a role in the cAMP regulation of mRNA stability
  • with HABP4, might be involved in nuclear functions like the remodeling of chromatin
  • SERBP1 affects HR-mediated DNA repair in response to DNA DSBs by regulation of RBBP8 translation in S phase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • SPIN1, via its Tudor-like domain, forms a ribonucleoprotein complex with SERBP1, and regulating mRNA stability and/or translation
  • INTERACTION
    DNA
    RNA binding to an RNA sequence in the plasminogen activator-inhibitor mRNA
    small molecule
    protein
  • interacts with CHD3 via two regions at its N- and C-terminals (chromo-helicase-DNA-binding domain protein CHD3 interacting protein)
  • with DAXX, TOPORS, PIASY, and UBA2
  • SPIN1, a maternal protein containing Tudor-like domains, interacts with a known mRNA-binding protein SERBP1, and is involved in regulating maternal transcripts to control meiotic resumption
  • SERBP1 regulates RBBP8 expression at the translational level in S phase
  • SERBP1 and ILF3 were identified as NR5A2 interacting partners
  • SERBP1 interacting selectively with RACK1, mediated by an extensive interaction surface on both proteins
  • cell & other
    REGULATION
    Other RG-rich and RGG box of SERBP1 is asymmetrically dimethylated by PRMT1 and the modification affects protein interaction and intracellular localization of the protein
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in human breast cancer, correlated with favourable prognosis
    Susceptibility
    Variant & Polymorphism
  • PAI-1 genotype 5G5G appears protective on survival following open aneurysm repair
  • 4G allele of the 4G5G polymorphism may be a risk factor for IgE-mediated asthma and allergic diseases
  • Candidate gene
    Marker
  • may represent a novel breast tumour marker with prognostic significance
  • Therapy target
    ANIMAL & CELL MODELS