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FLASH GENE
Symbol SEPTIN8 contributors: SGE, mct - updated : 28-08-2019
HGNC name septin 8
HGNC id 16511
Location 5q31.1      Physical location : -
Synonym name Drosophila melanogaster SEP2 and S cerevisiae CDC12 (homolog)
Synonym symbol(s) KIAA0202, SEP2, SEPT8
DNA
TYPE functioning gene
STRUCTURE 27.40 kb     10 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 2889 - 483 - 2003 12909369
isoform A
10 - 4076 - 442 - 2003 12909369
isoform C
10 - 4270 - 369 - 2003 12909369
isoform D
10 - 4344 - 429 - 2003 12909369
isoform B
10 - 3935 - 440 - 2003 12909369
10 - 4203 - 427 - 2003 12909369
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
 vesselaorta  predominantly
Nervousbrain     Homo sapiens
Urinarykidney   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticplatelet
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an ATP/GTP-binding site motif A (P loop)
  • conjugated PhosphoP
    mono polymer heteromer , oligo
    HOMOLOGY
    interspecies homolog to Drosophila melanogaster SEP2
    homolog to yeast S.cerevisiae CDC12
    homolog to murine Sept8 (98.4pc)
    Homologene
    FAMILY
  • GTP/GDP-binding proteins family
  • CATEGORY chaperone/stress , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,cytoplasm,cytoskeleton,microtubule
    text localized surrounding alpha-granules
    basic FUNCTION
  • putative cytoskeletal protein required for cytokinesis and cellular morphogenesis
  • GTPase that assemble as filamentous scaffolds
  • involved in the organization of submembranous structures, in neuronal polarity, and in vesicle trafficking
  • may be playing a functional role in platelet granular secretion
  • playing a role in the development of proliferative retinal membranes
  • CELLULAR PROCESS cell cycle, division
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heteroligomeric protein complex forming filaments
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP binding
  • protein
  • PNUTL1
  • SEPT5
  • interacting with CDK14, SEPT4, SEPT7
  • SEPT8 suppresses the interaction between VAMP2 and synaptophysin through binding to VAMP2
  • SEPTIN8 modulates likely bta-amyloidogenic processing of APP through a mechanism affecting the intracellular sorting and accumulation of BACE1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS