SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus,nucleoplasm,nuclear bodies
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text
| in mature human spermatozoa, SEPT12 and NDC1 are majorly colocalized in the centrosome regions; however, NDC1 is only slightly co-expressed with SEPT12 at the annulus of the sperm tail  |
basic FUNCTION
| may be involved in mammalian fertility  |
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filament-forming GTP-binding protein involved in a variety of cellular process such as cytokinesis, exocytosis, and membrane dynamics  |
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polymerizing GTP-binding protein required for many cellular functions, such as membrane compartmentalization, vesicular trafficking, mitosis, and cytoskeletal remodeling  |
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its expression levels are critical for mammalian spermiogenesis  |
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vital roles in sperm head shaping, nuclear DNA condensation, and early embryonic development  |
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testis-specific gene critical for the terminal differentiation of male germ cells  |
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vital roles of SEPT12 in sperm nuclear integrity and tail development  |
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SEPTIN12-microtubule complexes are critical for sperm formation during spermiogenesis  |
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is likely vital for the formation of sperm morphological characteristics during spermiogenesis  |