SUBCELLULAR LOCALIZATION
| intracellular
|
| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
|
| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
|
| intracellular,nucleus,nucleoplasm,nuclear bodies
|
text
| in mature human spermatozoa, SEPT12 and NDC1 are majorly colocalized in the centrosome regions; however, NDC1 is only slightly co-expressed with SEPT12 at the annulus of the sperm tail |
basic FUNCTION
| may be involved in mammalian fertility |
|
filament-forming GTP-binding protein involved in a variety of cellular process such as cytokinesis, exocytosis, and membrane dynamics |
|
polymerizing GTP-binding protein required for many cellular functions, such as membrane compartmentalization, vesicular trafficking, mitosis, and cytoskeletal remodeling |
|
its expression levels are critical for mammalian spermiogenesis |
|
vital roles in sperm head shaping, nuclear DNA condensation, and early embryonic development |
|
testis-specific gene critical for the terminal differentiation of male germ cells |
|
vital roles of SEPT12 in sperm nuclear integrity and tail development |
|
SEPTIN12-microtubule complexes are critical for sperm formation during spermiogenesis |
|
is likely vital for the formation of sperm morphological characteristics during spermiogenesis |