Selected-GenAtlas references SOURCE GeneCards NCBI Gene Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SEPTIN10 contributors: mct/npt - updated : 29-08-2019
HGNC name septin 10
HGNC id 14349
Location 2q13      Physical location : -
Synonym name sept1-like
Synonym symbol(s) FLJ11619, SEPT10
DNA
TYPE functioning gene
STRUCTURE 71.41 kb     11 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 splicing 3200 - 431 - 2010 20195767
11 splicing 3269 - 454 - 2010 20195767
5 - 4036 - 169 - 2010 20195767
7 - 2444 - 264 - 2010 20195767
6 - 4169 - 260 - 2010 20195767
6 - 4223 - 166 - 2010 20195767
8 - 2631 - 261 - 2010 20195767
7 - 4356 - 257 - 2010 20195767
8 - 4537 - 336 - 2010 20195767
11 - 4670 - 427 - 2010 20195767
8 - 2513 - 287 - 2010 20195767
7 - 4238 - 283 - 2010 20195767
9 - 2700 - 321 - 2010 20195767
12 - 3097 - 544 - 2010 20195767
10 - 4739 - 450 - 2010 20195767
11 - 3018 - 412 - 2010 20195767
10 - 4743 - 408 - 2010 20195767
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
 vesselsaorta   
Digestiveliver    
Reproductivefemale systemplacenta   
Respiratorylung    
Urinarykidney    
cells
SystemCellPubmedSpeciesStageRna symbol
Endocrineislet cell (alpha,beta...)
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
intraspecies homolog to SEPT8, SEPT6
homolog to SEPT14
Homologene
FAMILY
  • septin family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    text localize in cytoplasm and nucleus, with a subcellular pattern independent of the filamentous state of actin (Sui 2003)
    basic FUNCTION
  • involved in cytokinesis
  • cytoskeletal proteins with GTPase activity involved in various cellular biological processes (Sui 2003)
  • SEPT10 is an important regulator for microtubule stability
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in IGHV3-21 chronic lymphocytic leukemia with poor clinical outcome (Benedetti 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • may be a novel candidate molecule that acts as a good indicator of paclitaxel-resistant carcinomas
  • Marker
    Therapy target
    ANIMAL & CELL MODELS