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FLASH GENE
Symbol SEPHS1 contributors: mct - updated : 21-10-2010
HGNC name selenophosphate synthetase 1
HGNC id 19685
Location 10p13      Physical location : 13.360.082 - 13.390.280
Synonym name
  • selenium donor protein
  • selenophosphate synthase
  • selenide, water dikinase 1
  • Synonym symbol(s) SPS, SELD, SPS1, MGC4980
    EC.number 2.7.9.3
    DNA
    TYPE functioning gene
    STRUCTURE 30.88 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    Physical map
    USP6NL 10p13 USP6 N-terminal like ECHDC3 10p14 enoyl Coenzyme A hydratase domain containing 3 C10orf47 10p14 chromosome 10 open reading frame 47 UPF2 10p14-p13 UPF2 regulator of nonsense transcripts homolog (yeast) DHTKD1 10p14 dehydrogenase E1 and transketolase domain containing 1 SEC61A2 10p14 dehydrogenase E1 and transketolase domain containing 1 NUDT5 10p14-p13 nudix (nucleoside diphosphate linked moiety X)-type motif 5 C10orf7 10p13 chromosome 10 open reading frame 7 CAMK1D 10p13 calcium/calmodulin-dependent protein kinase ID DKFZP761F241 10p14 hypothetical protein DKFZp761F241 LOC389939 10 similar to ribosomal protein L5 OPTN 10p14 optineurin MCM10 10p13 MCM10 minichromosome maintenance deficient 10 (S. cerevisiae) LOC221044 10p14 hypothetical protein BC018068 PHYH 10p15-p14 phytanoyl-CoA hydroxylase (Refsum disease) SEPHS1 10p14 selenophosphate synthetase 1 C10orf30 10p14 chromosome 10 open reading frame 30 PRPF18 10p12.33 PRP18 pre-mRNA processing factor 18 homolog (yeast) FLJ10210 C10orf45 10p14 chromosome 10 open reading frame 45 LOC283071 10p14 similar to hypothetical protein 9330140G23 HSP70-4 10p14 likely ortholog of mouse heat shock protein, 70 kDa 4 SUV39H2 10p13 suppressor of variegation 3-9 homolog 2 (Drosophila) DCLRE1C 10p14-p13 DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae) LOC389940 10 similar to seven transmembrane helix receptor FLJ11106 10p13 hypothetical protein FLJ11106 LOC387634 10 similar to Acyl-CoA-binding protein (ACBP) (Diazepam binding inhibitor) (DBI) (Endozepine) (EP) MGC35468 10p13 hypothetical protein MGC35468 RPP38 10p13 ribonuclease P (38kD)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 splicing 3275 42.9 392 in B cells 2010 20471958
  • lacking exon 9
  • gradually increased until the G2/M phase and then decreased
  • 8 splicing 3004 - 325 cytoplasmic, kidney 2010 20471958
  • isoform delta E2, lacking exon 2
  • peaked at mid-S phase and then gradually decreased
  • 8 splicing 2399 - 321 cytoplasmic, breast tissues 2010 20471958
  • isoform delta E8, lacking exon 8
  • gradually increased until the G2/M phase and then decreased
  • 10 splicing 2675 - 324 cytoplasmic, in B cells 2010 20471958
  • also called SEPHS1 +E9
  • added exon 9
  • decreased gradually as time lapsed suggesting the formation of +E9/+E9a was impaired by synchronization
  • 10 splicing 2704 - 324 cytoplasmic, in B cells 2010 20471958
  • also called SEP¨HS1 +E9a
  • added exon 9, generated by attaching a part of intron 9 to the exon 9 by mis-splicing
  • decreased gradually as time lapsed suggesting the formation of +E9/+E9a was impaired by synchronization
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrineplacenta    
    Reproductivefemale systemplacenta   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    cell cycle     cell cycle, G2M, M exit
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine 1110046B24Rik
    homolog to rattus LOC291314
    homolog to drosophila patufet
    intraspecies homolog to SEPHS2
    Homologene
    FAMILY
  • selenophosphate synthetase family
  • class II subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • able to affect cell viability upon ionizing radiation via modulation of TP53 activity
  • might be involved in cancer prevention in a TP53-dependent manner and could be applied to development of a novel cancer therapy
  • participates in pathways important for cell viability
  • participates in the regulation of oxidative stress and cell growth
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP and GTP binding
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS