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FLASH GENE
Symbol SEPHS1 contributors: mct - updated : 21-10-2010
HGNC name selenophosphate synthetase 1
HGNC id 19685
Location 10p13      Physical location : 13.360.082 - 13.390.280
Synonym name
  • selenium donor protein
  • selenophosphate synthase
  • selenide, water dikinase 1
  • Synonym symbol(s) SPS, SELD, SPS1, MGC4980
    EC.number 2.7.9.3
    DNA
    TYPE functioning gene
    STRUCTURE 30.88 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 splicing 3275 42.9 392 in B cells 2010 20471958
  • lacking exon 9
  • gradually increased until the G2/M phase and then decreased
  • 8 splicing 3004 - 325 cytoplasmic, kidney 2010 20471958
  • isoform delta E2, lacking exon 2
  • peaked at mid-S phase and then gradually decreased
  • 8 splicing 2399 - 321 cytoplasmic, breast tissues 2010 20471958
  • isoform delta E8, lacking exon 8
  • gradually increased until the G2/M phase and then decreased
  • 10 splicing 2675 - 324 cytoplasmic, in B cells 2010 20471958
  • also called SEPHS1 +E9
  • added exon 9
  • decreased gradually as time lapsed suggesting the formation of +E9/+E9a was impaired by synchronization
  • 10 splicing 2704 - 324 cytoplasmic, in B cells 2010 20471958
  • also called SEP¨HS1 +E9a
  • added exon 9, generated by attaching a part of intron 9 to the exon 9 by mis-splicing
  • decreased gradually as time lapsed suggesting the formation of +E9/+E9a was impaired by synchronization
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrineplacenta    
    Reproductivefemale systemplacenta   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    cell cycle     cell cycle, G2M, M exit
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine 1110046B24Rik
    homolog to rattus LOC291314
    homolog to drosophila patufet
    intraspecies homolog to SEPHS2
    Homologene
    FAMILY
  • selenophosphate synthetase family
  • class II subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • able to affect cell viability upon ionizing radiation via modulation of TP53 activity
  • might be involved in cancer prevention in a TP53-dependent manner and could be applied to development of a novel cancer therapy
  • participates in pathways important for cell viability
  • participates in the regulation of oxidative stress and cell growth
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP and GTP binding
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS