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FLASH GENE
Symbol SENP8 contributors: mct/pgu - updated : 14-04-2015
HGNC name SUMO/sentrin specific protease family member 8
HGNC id 22992
Location 15q23      Physical location : 72.406.598 - 72.433.310
Synonym name
  • sentrin/SUMO-specific protease SENP8
  • deneddylase 1
  • NEDD8-specific protease 1
  • protease, cysteine, 2 (NEDD8 specific)
  • Synonym symbol(s) DEN1, PRSC2, NEDP1
    EC.number 3.4.22.68
    DNA
    TYPE functioning gene
    STRUCTURE 26.71 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1680 - 212 - 2003 12759362
    3 - 1834 - 212 - 2003 12759362
    3 - 1676 - 212 - 2003 12759362
    3 - 1693 - 212 - 2003 12759362
    2 - 1569 - 212 - 2003 12759362
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbraindiencephalonhypothalamus  
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Prsc2
    Homologene
    FAMILY peptidase family C48
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in the release of sentrins
  • proteases with specificity for hydrolysis of NEDD8 derivatives, playing an unique role in regulating the modification of cullins by NEDD8
  • is a proximal regulator of Cul neddylation and provide an important role for SENP8 in fine-tuning the inflammatory response
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • deconjugating cullin 1 (CUL1)-NEDD8 in a concentration-dependent manner
  • discriminates between NEDD8 and ubiquitin
  • promoted the interaction between E2F1 and its cofactor MCPH1, which is required for TP73 induction
  • key regulator of Cul neddylation response
  • GPS1 targets SENP8 for protein degradation, and GPS1-SENP8 interaction that affects SENP8 protein levels presumably balances cellular deneddylase activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS