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FLASH GENE
Symbol SENP6 contributors: mct - updated : 26-08-2011
HGNC name SUMO1/sentrin specific peptidase 6
HGNC id 20944
Location 6q14.1      Physical location : 76.311.621 - 76.427.993
Synonym name
  • SUMO-1-specific protease
  • Synonym symbol(s) KIAA0797, SSP1, SUSP1, FLJ11355, KIAA0389
    EC.number 3.4.22.-
    DNA
    TYPE functioning gene
    STRUCTURE 116.38 kb     24 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 - 6645 - 1112 - 2011 21148299
    23 - 6624 - 1105 - 2011 21148299
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinelarge intestinecolon  
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systemovary  highly
     female systemuterus  moderately
     male systemtestis  moderately
     male systemprostate   
    Respiratorylung   moderately
     respiratory tractlarynx  predominantly
    Urinarybladder   highly
     kidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • conserved histidine, aspartic acid and cysteine residues of the catalytic triad
  • conserved sequence insertions in distinct positions within the catalytic domain
  • a unique sequence insertion in the SENP6 and SENP7 subclass that is essential for their proteolytic activity and that forms a more extensive interface with SUMO during the proteolytic reaction
  • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Senp6
    ortholog to chimpanzee senp6
    Homologene
    FAMILY
  • peptidase C48 family
  • SENP/ULP protease family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • regulation of SUMO1 mediated cellular processes particulary related to reproduction
  • acting as a protease that releases SUMO-1 from its precursor sequence
  • acting as a thiol protease
  • exhibit specificity for SUMO2/3, especially when poly-SUMO2 or poly-SUMO3 chains are used as substrates (Lima 2008)
  • finely balanced activities of SENP6 and RNF4 control vertebrate kinetochore assembly through SUMO-targeted destabilization of inner plate components
  • SUMO protease that is a direct regulator of PML (Promyelocytic leukemia protein) nuclear bodies
  • SENP6 and SENP7 subclass displays a clear proteolytic cleavage preference for SUMO2/3 isoforms
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • Ubl conjugation pathway
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS