Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SENP5 contributors: mct/npt - updated : 20-01-2009
HGNC name SUMO1/sentrin specific peptidase 5
HGNC id 28407
Location 3q29      Physical location : 196.594.726 - 196.661.582
Synonym name
  • SUMO1/smt3-specific isopeptidase
  • SUMO1/sentrin specific protease 5
  • Synonym symbol(s) SMT3B1, LOC205564 , MGC27076, AXAM1, SMT3IP1, FKSG45, FLJ42398, DKFZp564O1016
    EC.number 3.4.22.-
    DNA
    TYPE functioning gene
    STRUCTURE 63.32 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - D3S3305E - D3D2348 - SENP5 - D3S1770 - D3S4370 - qter
    Authors UCSC (2009)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 6324 86 755 - Di Bacco (2006)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   highly
     mouth   highly
    Nervousbraindiencephalonamygdala  
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, interphase
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • SUMO C-terminal hydrolase catalytic domain
  • HOMOLOGY
    interspecies homolog to yeast ulp1
    intraspecies homolog to SENP1 or SUSP1
    Homologene
    FAMILY
  • peptidase C48 family
  • Ulp/SENP family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    text localize within the granular component of the nucleolus, a subnucleolar compartment that contains B23/nucleophosmin
    basic FUNCTION
  • catalyzes the cleavage of SUMO1 from a number of mitochondrial substrates (importance of SENP5 as a new regulator of SUMO1 proteolysis from mitochondrial targets, impacting mitochondrial morphology and metabolism) (Zunino 2007)
  • SUMO-specific protease required for cell division and playing an essential role in mitosis and/or cytokinesis (Di Bacco 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with NPM1 (Yun 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in oral squamous cell carcinoma and associated with differentiation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS