basic FUNCTION
| having an essential role in the G2/M phase of the cell cycle |
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may down-regulate CTNNB1 levels and thereby modulate the WNT pathway |
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exhibits a slight preference for SUMO2/3 over SUMO1 |
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processing newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species |
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desumoylating enzyme playing a critical role in the control of adipogenesis |
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desumoylating and stabilizing CEBP and in turn promoting the expression of its downstream effectors such as PPAR gamma and CEBPA |
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catalyzing SUMO deconjugation more efficiently than processing |
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catalyzes the desumoylation process of MDM2 |
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SENP2-mediated regulation of MDM2 is critical for genome integrity in TP53-dependent stress responses |
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can efficiently associate with IKBKG, deSUMOylate IKBKG, and inhibit NFKB activation induced by DNA damage |
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chromosome segregation depends on precise spatial and temporal control of sumoylation in mitosis and SENP1 and SENP2 are important mediators of this control |
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