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FLASH GENE
Symbol SENP2 contributors: mct - updated : 06-07-2012
HGNC name SUMO1/sentrin/SMT3 specific peptidase 2
HGNC id 23116
Location 3q27.2      Physical location : 185.304.030 - 185.348.883
Synonym name
  • SUMO1/Smt3-specific isopeptidase
  • sentrin-specific protease 2
  • SMT3-specific isopeptidase 2
  • sentrin/SUMO-specific protease SENP2
  • Synonym symbol(s) KIAA1331, SMT3IP2, AXAM2, DKFZp762A2316
    EC.number 3.4.22.-
    DNA
    TYPE functioning gene
    STRUCTURE 44.85 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif Viral sequence   long terminal repeat
    text structure specific HERV-K LTR 15 kb upstream
    MAPPING cloned   linked   status
    Physical map
    POLR2H 3q28 polymerase (RNA) II (DNA directed) polypeptide H THPO 3q27-q28 thrombopoietin (myeloproliferative leukemia virus oncogene ligand, megakaryocyte growth and development factor) CHRD 3q27 chordin LOC285248 3q27.3 hypothetical LOC285248 LOC391600 3 similar to RIKEN cDNA 2310042E22 EPHB3 3q21-qter EphB3 MAGEF1 3q13 EphB3 LOC389182 3 LOC389182 KIAA0804 3q28 LOC389182 LOC285382 3q28 hypothetical gene supported by AK091454 LOC339926 3q28 hypothetical LOC339926 LOC391601 3 similar to alpha-1 platein precursor EHHADH 3q26.3-q28 enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase LOC347673 3q26.3-q28 eukaryotic translation initiation factor 2 beta-like pseudogene MAP3K13 3q27 mitogen-activated protein kinase kinase kinase 13 MGC15397 3q28 similar to RIKEN cDNA 5730578N08 gene LIPH 3q27-q28 lipase, member H SENP2 3q28 lipase, member H IMP-2 3q28 IGF-II mRNA-binding protein 2 SFRS10 3q26.2-q27 splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) LOC344887 3q28 similar to RIKEN cDNA 1110025F24 ETV5 3q28 ets variant gene 5 (ets-related molecule) DGKG 3q27-q28 diacylglycerol kinase, gamma 90kDa CRYGS 3q25-q28 crystallin, gamma S FLJ10560 3q28 hypothetical protein FLJ10560 DNAJB11 3q28 DnaJ (Hsp40) homolog, subfamily B, member 11 AHSG 3q27 alpha-2-HS-glycoprotein FETUB 3q27 fetuin B HRG 3q27 histidine-rich glycoprotein LOC391602 3 similar to Histidine-rich glycoprotein precursor (Histidine-proline rich glycoprotein) (HPRG) KNG 3q27 kininogen LOC280644 3q28 proteasome 26S non-ATPase subunit 10 pseudogene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 3207 - 589 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Digestivemouth   highly
    Endocrineadrenal gland   highly
    Nervousbrain    
    Reproductivemale systemtestis  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-terminal catalytic domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Senp2 (87.4pc)
    homolog to murine Senp2 (88.4pc)
    Homologene
    FAMILY
  • ULP1 protease family
  • peptidase C48 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nuclear envelope,pore
    text
  • nucleoplasmic face of the nuclear pore complex
  • shuttles between cytoplasm and nucleus
  • basic FUNCTION
  • having an essential role in the G2/M phase of the cell cycle
  • may down-regulate CTNNB1 levels and thereby modulate the WNT pathway
  • exhibits a slight preference for SUMO2/3 over SUMO1
  • processing newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species
  • desumoylating enzyme playing a critical role in the control of adipogenesis
  • desumoylating and stabilizing CEBP and in turn promoting the expression of its downstream effectors such as PPAR gamma and CEBPA
  • catalyzing SUMO deconjugation more efficiently than processing
  • catalyzes the desumoylation process of MDM2
  • SENP2-mediated regulation of MDM2 is critical for genome integrity in TP53-dependent stress responses
  • can efficiently associate with IKBKG, deSUMOylate IKBKG, and inhibit NFKB activation induced by DNA damage
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to NUP153, through the C-terminal domain via its N-terminus
  • binding to SMT3H1 and SMT3H2
  • binding ti SUMO2 and SUMO3
  • SENP2-dependent regulation of MDM2 is sensitive to its TP53-binding activity
  • both SENP1 and -2 induce deSUMOylation of GJA1
  • NUP153 binds to both SENP1 and SENP2 and does so by interacting with the unique N-terminal domain of NUP153 as well as a specific region within the C-terminal FG-rich region
  • SENP2 and SENP7 (two SUMOylation proteases) decreased SUMOylation of ATF3
  • cell & other
    REGULATION
    induced by NFKB (NFKB induces SENP2 transcription selectively in response to genotoxic stimuli, which involves ataxia telangiectasia mutated (ATM)-dependent histone methylation of SENP2 promoter KB regions and NFKB recruitment)
    Other polyubiquitinated leading to proteasomal degradation
    increased upon the induction of adipocytes differentiation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS