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FLASH GENE
Symbol SENP1 contributors: mct/ - updated : 09-07-2019
HGNC name SUMO1/sentrin specific peptidase 1
HGNC id 17927
Location 12q13.11      Physical location : 48.436.757 - 48.499.641
Synonym name
  • sentrin specific protease
  • sentrin/SUMO-specific protease 1
  • Synonym symbol(s) SuPr-2
    EC.number 3.4.22.68
    DNA
    TYPE functioning gene
    STRUCTURE 62.88 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    AMIGO2 12q13.11 amphoterin induced gene 2 MGC16044 12q13.11 hypothetical protein MGC16044 LOC387854 12 LOC387854 LOC387855 12 LOC387855 FLJ21908 12q13.11 hypothetical protein FLJ21908 P11 12q13.1 26 serine protease EPAC 12q13.1 Rap1 guanine-nucleotide-exchange factor directly activated by cAMP FLJ20489 12q13.11 hypothetical protein FLJ20489 HDAC7A 12q13.1 histone deacetylase 7A VDR 12q13.1 vitamin D (1,25- dihydroxyvitamin D3) receptor MGC5576 12q13.1 hypothetical protein MGC5576 COL2A1 12q13.1 collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital) LOC283389 12q13.12 hypothetical gene supported by BC029593 SENP1 12q12-q13 hypothetical gene supported by BC029593 PFKM 12q13.1 phosphofructokinase, muscle ASB8 12q13.12 ankyrin repeat and SOCS box-containing 8 LOC390311 12 similar to prohibitin LOC387856 12 similar to expressed sequence AI836003 LOC121275 12q13.12 similar to Olfactory receptor 10AD1 LOC341567 12q13.12 HANP1 FLJ31295 12q13.12 hypothetical protein FLJ31295 LOC390312 12 similar to olfactory receptor MOR160-1 ANP32D 12p11.1 acidic (leucine-rich) nuclear phosphoprotein 32 family, member D MGC35033 12q13.12 hypothetical protein MGC35033 LOC341568 12q13.12 similar to seven transmembrane helix receptor LOC390313 12 similar to seven transmembrane helix receptor LALBA 12q13.1 lactalbumin, alpha- LOC121270 12q13.12 similar to olfactory receptor MOR122-1 FLJ20436 12q13.12 hypothetical protein FLJ20436 CCNT1 12q13.1 cyclin T1 LOC255411 12q13.12 hypothetical LOC255411 ADCY6 12q12-q13 adenylate cyclase 6 LOC390314 12 similar to Protein C20orf27 CACNB3 12q13 calcium channel, voltage-dependent, beta 3 subunit DDX23 12q13.12 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 RHO6 12q12-q13 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 NYD-SP28 12q13.12 NYD-SP28 protein FKBP11 12q13.2 FK506 binding protein 11, 19 kDa ARF3 12q13.1 ADP-ribosylation factor 3 WNT10B 12q13.1 wingless-type MMTV integration site family, member 10B
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 4726 73.2 643 - 2018 30305424
    18 - 4456 - 644 - 2018 30305424
    18 - 4803 - 644 - 2018 30305424
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   moderately
    Digestivemouthtongue  moderately
    Endocrinepancreas    
    Lymphoid/Immunelymph node   moderately
     thymus   highly
    Nervousbrain    
    Reproductivemale systemprostate  highly Homo sapiens
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a catalytic domain (SENP1C) that can determine the substrate specificity towards SUMO-1, -2 and -3
  • HOMOLOGY
    interspecies homolog to yeast Smt3-s specific protease
    ortholog to murine Senp1
    Homologene
    FAMILY
  • peptidase C48 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nuclear envelope
    text
  • its localization is influenced by expression and localization of SUMO1-conjugated target proteins within the cell
  • SUMO-specific isopeptidases SENP1 and SENP2 are targeted to kinetochores in mitosis
  • basic FUNCTION
  • sentrin-specific protease that preferentially removes sentrin from sentrinized proteins in the nucleus
  • SUMO-specific proteases involved in the regulation of apoptosis
  • degrading UBL1 and SMT3H2 conjugates and releases the monomers
  • acting on sumoylated PML
  • acting as a thiol protease
  • involved in Ubl conjugation pathway
  • enhancing the transcription activity of c-Jun
  • playing a role in desumoylation
  • promotes stress-induced apoptosis by interacting with and desumoylating SIRT1
  • playing a key role in the regulation of the hypoxic response through regulation of HIF1alpha stability
  • controlling Epo production
  • may itself be a target for SUMO1 modification occurring at a nonconsensus site
  • lacks a clear preference for any particular SUMO isoform
  • important role in the de-SUMOylation of ELK1, and therefore an integral role in determining the ELK1-dependent transcriptional programme
  • important role in the regulation of ELK1-mediated gene expression in response to mitogenic signalling cues
  • could abrogate CAPN2 sumoylation, causing an inhibition on calpain-2-dependent activity and cell motility
  • alters VEGF levels by directly regulating HIF1A stability during fetal development
  • participates in the development of prostate neoplasia
  • regulates VEGF expression via modulating the nuclear stability of HIF1A and initiates the onset of angiogenesis in DYNLL1
  • is essential for the development of early T and B cells
  • essential role of SENP1 in PPARGC1A transcriptional activity and also in mitochondrial biogenesis
  • is essential for expression of nuclear mitochondrial genes
  • SENP1 can promote the expression of mitochondrial genes through de-SUMOylation
  • critical role for SENP1-mediated deSUMOylation in promoting PIN1 function during tumorigenesis
  • chromosome segregation depends on precise spatial and temporal control of sumoylation in mitosis and SENP1 and SENP2 are important mediators of this control
  • is a novel regulator in adipogenesis
  • is an important regulation protease in the protein sumoylation, which affects the cell cycle, proliferation and differentiation
  • SENP1 and the chromatin remodeler CHD3 interact and jointly affect chromatin accessibility and gene expression
  • SENP1 is an essential regulator of the balance between SUMOylation and deSUMOylation during lung development, specifically affecting the proliferation and differentiation status of AT2 cells
  • SENP1 promotes sepsis via activating the TGFBR2 signaling
  • CELLULAR PROCESS cell life, cell death/apoptosis
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • markedly enhances the transcription activity of JUN (independent of the sumoylation and phosphorylation status of JUN but is critically dependent on the desumoylation activity of SENP1)
  • interacting with EP300 (essential for SENP1 to enhance JUN-dependent transcription because SENP1 can desumoylate the CRD1 domain of EP300, thereby releasing the cis-repression of CRD1 on EP300)
  • promotes GATA1 activation and subsequent erythropoiesis by deSUMOylating GATA1
  • reverses SUMOylation of MAML1 and potentiates the transcription factor activity of MAML1
  • STAT5B is a key regulator of lymphoid development, that is modified by SUMO-2 and is specifically regulated by SENP1
  • crucial role of SENP1 in the regulation of STAT5B activation during early lymphoid development
  • both SENP1 and -2 induce deSUMOylation of gJA1
  • NUP153 binds to both SENP1 and SENP2 and does so by interacting with the unique N-terminal domain of NUP153 as well as a specific region within the C-terminal FG-rich region
  • SENP1 is a specific SUMO protease to regulate SUMOylation status of PPARGC1A
  • SUMOylation of PPARGC1A controlled by SENP1 plays an important role in mitochondrial biogenesis and function
  • SENP1 is a specific de-SUMOylation protease for BHLHE41, a repressor for PPARG transcription and adipogenesis
  • SENP1 can deSUMOylate SUMOylated HMGN2, and PIAS1 is the E3 ligase responsible for SUMOylation of HMGN2
  • key role for SENP1 in IL6 induced proliferation and survival of multiple myeloma cells
  • SENP1-mediated IKBKG deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression
  • SUMO1 conjugation of RB1 and LMNA is modulated by the SUMO protease SENP1 and sumoylation of both proteins is required for their interaction
  • SENP1 deconjugates SUMO from modified proteins
  • SENP1 likely plays a neuroprotective role in I/R injury by inhibiting apoptosis through decreasing SUMO1 conjugation
  • only NUP153 is needed for proper nuclear import of TP53BP1 and SENP1-dependent sumoylation of TP53BP1
  • SENP1 is the specific deSUMOylation enzyme for GLI1, and negatively regulate SHH signaling
  • SENP1 attenuates the liver fibrosis through down-regulating the expression of SMAD2
  • SENP1 physically interacts with the chromatin remodeler chromodomain helicase DNA-binding protein 3 (CHD3)
  • SENP1 is a crucial MYC deSUMOylating enzyme that positively regulates MYC stability and activity
  • interaction of SENP1 with SUMO2 (C-terminal motif (QQTGG) of SUMO2 is stabilized by a number of specific bonding interactions that enable it to protrude into the catalytic triad of SENP1 and provide the arrangement necessary for maturation of SUMO and deSUMOylation activity)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in NPM-ALK positive anaplastic large cells lymphoma
    tumoral     --over  
    in prostate cancer and correlates with hypoxia-inducing factor 1&945; (HIF1A) expression
    constitutional   deletion    
    SENP1 deletion in adipocytes enhances SUMOylation of the NFKB1 essential molecule, IKBKG, at lysine 277/309, leading to increased NFKB1 activity, cytokine production and pancreatic inflammation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    may be a potential new therapeutic target in multiple myeloma
    ANIMAL & CELL MODELS
    Senp1 (-/-) mouse embryos show severe fetal anemia stemming from deficient Erythropoietin production and die midgestation