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FLASH GENE

Symbol

SEMG2

contributors: mct - updated : 05-01-2007

HGNC name	semenogelin II
HGNC id	10743

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	20q13.1      Physical location : 43.850.009 - 43.853.098
Synonym symbol(s)	SGII

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
text	located 3' to SEMG1 in a head to tail arrangement
STRUCTURE	3.00 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system seminal vesicles         male system male genital tract epididymis       male system prostate         male system male genital tract vas deferens     Respiratory respiratory tract trachea

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage
cell lines
fluid/secretion	semen

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a signal peptide C terminal non coding nucleotide

HOMOLOGY

interspecies

homolog to murine Syp3

Homologene

FAMILY

semenogelin family

CATEGORY

secretory

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	formation of a gel matrix entrapping the accessory gland secretion and ejaculated spermatozoa
	participating in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions
	and ejaculated spermatozoa

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

major constituent protein of seminal fluid

INTERACTION

DNA

RNA

small molecule

protein	binding semenogelins I and zinc and regulate the activity of prostate-specific antigen (KLK3)
	cleaved by KLK14

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS