| basic FUNCTION
| putative counterpart of the viral semaphorin VB |
|
playing an important role in modulating immune response |
|
enhancing central and peripheral axon growth and required for proper axon tract formation during embryonic development (through MAPK-dependent signaling activation) |
|
potent monocytes stimulator increasing granulocyte-macrophage colony-stimulating factor (GM-CSF) production from monocytes |
|
might be a molecule involved in the terminal innervation of the dentin-pulp complex |
|
possible involvement in bone cell differentiation  |
|
glycosylphosphatidylinositol-anchored semaphorin, promoting axon outgrowth through 1-integrin receptors and contributing to the formation of the lateral olfactory tract |
|
having a critical role in T-cell-mediated inflammation through ITGA1-ITGB1 integrin on macrophages |
|
has an essential function in the effector phase of cell-mediated immunity |
|
stimulates cytoskeletal reorganization in melanocytes and monocytes, which translates into cell morphology changes that can result in spreading and migration of these types of cells |
|
may be involved in regulating cell-sorting in the formation and regeneration of the periodontal attachment structure |
|
plays a central role in a PI3K/PKB/AKT-dependent pathway that contributes to TGF-beta1-induced fibrosis and remodeling |
|
induces significant melanocyte spreading and dendricity in human melanocytes |
|
involved in axon guidance, stimulates melanocyte adhesion and dendricity through opposing actions of beta1-integrin and Plexin C1 receptors |
|
activated mitogen-activated protein kinase and inactivated cofilin, and actin-binding protein involved in cell migration |
|
stimulates cytoskeletal reorganization in melanocytes, resulting in adhesion and dendrite formation |
|
SEMA7A on keratinocytes and ITGB1 on monocytes contribute to monocyte activation by keratinocytes within skin inflammation, such as psoriasis or wound |
|
acts as a positive regulator for thalamocortical axon branching and/or pre-synaptic puncta formation |
|
has important immunomodulatory functions in inflammatory responses, and it might play a key role in autoimmune diseases and other major disorders |
|
presence of hypoxia-inducible SEMA7A on endothelial cells, having a potential to promote transendothelial leukocyte migration |
|
facilitates increased transendothelial migration of neutrophils depending on the Plexin C1 receptor |
|
expressed in hepatic stellate cells (HSCs) with respect to other cell types in the liver and plays a critical role in regulating fibrosis |
|
is a potentially important modulator of eosinophil profibrotic functions in the airway remodeling of patients with chronic asthma (24333536) |
|
is a regulator of thalamocortical and local circuit development |
|
is critical in the development of lung inflammation and pulmonary edema in seawater aspiration-induced acute lung injury |
